膝骨关节炎和腰痛患者的脑低频振幅影像学特征比较

doi:10.3969/j.issn.1006-9771.2022.05.016

Abstract

Abstract:

Objective To compare the brain imaging characteristics in patients with knee osteoarthritis (KOA) and low back pain (LBP) based on amplitude of low frequency fluctuation (ALFF) of functional magnetic resonance imaging. Methods From August, 2015 to September, 2021, 16 KOA patients and 16 healthy subjects (controls 1) with similar age and gender were recruited from the communities of Fuzhou, Fujian. Other 27 patients with LBP and 32 healthy subjects (controls 2) with similar age and gender were obtained from the Openpain database. The ALFF were analyzed. KOA patients were assessed the pain with Brief Pain Inventory (BPI), and LBP patients were assessed with Visual Analogue Scale (VAS). The correlation between ALFF and pain scores was analyzed. Results Compared with their own controls, the ALFF decreased in the left anterior insula for both KOA and LBP patients. The ALFF decreased in the hippocampus and posterior cingulate cortex in KOA patients, while increased in LBP patients. ALFF in the left precuneus, left middle cingulate cortex and right periaqueductal gray matter decreased in KOA patients, and ALFF increased in the right precentral/postcentral gyrus. ALFF of bilateral anterior cingulate cortex, bilateral orbital anterior frontal cortex, left dorsolateral prefrontal cortex and right medial prefrontal cortex decreased in LBP patients, and ALFF increased in the right parahippocampal gyrus and right amygdala. ALFF of the left middle cingulate cortex negatively correlated with BPI score in KOA patients (r = -0.73, P = 0.003), and ALFF of the right hippocampus/amygdala positively correlated with VAS score in LBP patients (r = 0.73, P = 0.003). Conclusion There are common and specific brain imaging features in different types of chronic pain. The alteration in the left anterior insula, hippocampus and posterior cingulate gyrus may be the common mechanism for KOA and LBP.

Key words: knee osteoarthritis, low back pain, chronic pain, functional magnetic resonance imaging, amplitude of low frequency fluctuation

CLC Number:

R684

CAI Guiyan,CHEN Ruilin,XU Shurui,TAO Jing,LIU Jiao. Characteristics of amplitude of low frequency fluctuation in patients with knee osteoarthritis and low back pain[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 602-608.

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References 38

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组别	n	性别(男/女)/n	年龄/岁	BPI
HC1组	16	12/4	61.13±4.35	-
KOA组	16	11/5	61.13±4.35	3.38±0.89
χ²/t值		0.155	0.000
P值		0.694	1.000

组别	n	性别(男/女)/n	年龄/岁	VAS ^#
HC2组	32	18/14	30.63±9.25	-
腰痛组	27	12/15	30.89±11.73	4.52±1.75
χ²/t值		0.817	-0.097
P值		0.366	0.864

比较	脑区	体素值	t值	MNI坐标
比较	脑区	体素值	t值	X	Y	Z
HC1组 > KOA组	左楔前叶	156	5.20	-12	-60	42
	左前岛叶	75	5.05	-42	0	-21
	右后扣带回	105	5.14	18	-24	30
	右导水管周围灰质	89	4.99	15	-30	-30
	左中扣带回	83	4.41	-6	9	24
	右海马	69	4.38	39	3	-15
KOA组 > HC1组	右中央前回	101	5.14	48	-6	33
	右中央后回		3.19	51	-21	39

比较	脑区	体素值	t值	MNI坐标
比较	脑区	体素值	t值	X	Y	Z
HC2组 > 腰痛组	左背外侧前额叶	298	4.40	-33	3	36
	左前岛叶	355	4.19	-27	24	-6
	左眶部额前回		3.53	-30	30	0
	左前扣带回		3.32	-12	39	0
	右眶部额前回		3.59	39	33	-6
	右前扣带回		3.17	9	39	12
	右内侧前额叶		3.59	15	33	6
腰痛组 > HC2组	右海马/杏仁核	466	5.37	0	-39	-12
	左后扣带回		3.66	-9	-42	-3
	右海马旁回		3.50	18	-12	-27

Characteristics of amplitude of low frequency fluctuation in patients with knee osteoarthritis and low back pain

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