静息态脑功能磁共振成像在急性轻型脑外伤中的应用

doi:10.3969/j.issn.1006-9771.2022.09.012

Abstract

Abstract:

Objective To apply resting-state functional magnetic resonance imaging in acute mild traumatic brain injury.
Methods From May, 2019 to May, 2021, 47 cases with acute mild traumatic brain injury in Beijing Bo'ai Hospital were selected as observation group, and 50 healthy people who visited for routine physical examination during the same period were as control group. They were scanned with resting-state functional magnetic resonance imaging to measure amplitude of low-frequency fluctuation (ALFF), and they were assessed with Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and Rivermead Behavioural Memory Test (RBMT).
Results Compared with the control group, the scores of MMSE, MoCA and RBMT decreased in the observation group (t > 18.138, P < 0.001); while ALFF decreased in the brain areas of posterior cerebellar lobe, cerebellar tonsils, lower half moon lobules, right superior temporal gyrus, right middle temporal gyrus, right parietal lobe and right central posterior gyrus, etc; and ALFF increased in the brain areas of marginal lobe, cingulate gyrus, precuneus, left cerebellar, right superior temporal gyrus, right middle temporal gyrus, right superior frontal gyrus, right middle frontal gyrus, right inferior frontal gyrus, etc.
Conclusion There are disorders in multiple brain areas for patients after acute mild traumatic brain injury, which may associate to the cognitive impairment.

Key words: traumatic brain injury, functional magnetic resonance imaging, amplitude of low-frequency fluctuation, cognition

CLC Number:

R651.1

ZHANG Xiaoyu,YANG Fan,WEN Jianzhong,YU Weiyong. Application of resting-state functional magnetic resonance imaging in acute mild traumatic brain injury[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(9): 1084-1088.

Figures/Tables 3

References 33

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组别	n	性别(男/女)/n	年龄/岁	受教育程度/年	创伤原因(砸伤/车祸伤/高处坠落伤)/n
对照组	50	28/22	35.20±4.23	10.35±1.30
观察组	47	26/21	35.14±4.12	10.24±1.24	19/17/11
χ²/t值		0.019	0.071	0.427
P值		0.891	0.944	0.671

组别	n	MMSE	MoCA	RBMT
对照组	50	12.25±2.44	10.65±0.31	3.25±1.20
观察组	47	28.15±1.65	27.36±1.51	7.69±1.21
t值		37.360	76.553	18.138
P值		< 0.001	< 0.001	< 0.001

脑区	MNI峰坐标			t值	体素数
脑区	X	Y	Z	t值	体素数
区域1	18	-45	-61	-3.987	691
小脑后叶					330
小脑扁桃体					184
下半月小叶					72
区域2	70	-41	7	-4.822	438
右侧颞上回					162
右侧颞中回					120
右侧顶叶					73
右侧中央后回					70
区域3	-16	64	14	5.368	702
边缘叶					421
扣带回					324
左侧小脑					310
楔前叶					161
区域4	-52	-34	10	3.818	265
右侧颞上回					52
右侧颞中回					40
区域5	22	55	23	5.887	364
右侧额中回					77
右侧额上回					53
右侧额下回					41

Application of resting-state functional magnetic resonance imaging in acute mild traumatic brain injury

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