小脑间歇性θ短阵快速脉冲刺激对脑卒中患者下肢运动功能的影响

doi:10.3969/j.issn.1006-9771.2022.10.011

Abstract

Abstract:

Objective To observe the effect of cerebellar intermittent theta burst stimulation (iTBS) on lower extremity motor function in stroke patients.

Methods From March to December, 2021, 42 stroke patients in Rehabilitation Center of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected and divided into control group (n = 21) and observation group (n = 21) according to the random number table method. Both groups received routine medicine and rehabilitation therapy, as well as suspension training, including trunk control training, separation exercise strengthening training and alternating lower limb training. Before the suspension training, the observation group was intervened by repeated transcranial magnetic stimulation using the cerebellar iTBS mode, three pulses per plexus, the intra-cluster frequency of 50 Hz, the inter-cluster frequency of 5 Hz, and stimulated two seconds, intermited eight seconds, for 600 pulses. They were assessed with Fugl-Meyer Assessment-Lower Extremities (FMA-LE), Berg Balance Scale (BBS) and modified Barthel Index (MBI) before and four weeks after treatment, and the motor evoked potential (MEP) latencies were compared.

Results All the patients completed rehabilitation training with good compliance, and no adverse events occurred. After treatment, the scores of FMA-LE, BBS and MBI increased in both groups after treatment (|t| > 10.053, P < 0.001), while the MEP latency decreased (t = 5.326, P < 0.001) in the observation group, and the scores of FMA-LE and BBS, and MEP latency were better in the observation group than in the control group (|t| > 3.029, P< 0.01).

Conclusion Cerebellar iTBS can promote the recovery of lower extremity motor function in stroke patients.

Key words: stroke, suspension training, cerebellar theta-burst stimulation

CLC Number:

R743.3

WANG Shurui,LI Li. Effects of cerebellar theta-burst stimulation on lower extremity motor function in stroke patients[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(10): 1205-1210.

Figures/Tables 5

References 33

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组别	n	性别(男/女)/n	年龄/岁	病程/周	脑卒中性质(脑梗死/脑出血)/n	偏瘫侧(左/右)/n	Brunnstrom分期(Ⅱ期/Ⅲ期/Ⅳ期)/n
对照组	21	9/12	54.62±7.85	72.95±47.37	13/8	12/9	4/8/9
观察组	21	11/10	52.62±8.61	82.33±45.27	12/9	13/8	3/8/10
χ²/t值		0.382	0.787	-0.656	0.099	0.099	0.195
P值		0.537	0.436	0.516	0.753	0.753	0.907

组别	n	治疗前	治疗后	t值	P值
对照组	21	19.10±1.97	26.95±2.91	-10.053	< 0.001
观察组	21	18.86±2.69	29.76±2.19	-16.760	< 0.001
t值		0.327	-3.539
P值		0.745	< 0.001

组别	n	治疗前	治疗后	t值	P值
对照组	21	39.67±2.61	49.86±2.71	-11.475	< 0.001
观察组	21	40.24±2.05	52.14±2.15	-18.834	< 0.001
t值		-0.789	-3.029
P值		0.435	0.004

组别	n	治疗前	治疗后	t值	P值
对照组	21	44.33±8.85	73.90±10.92	-10.731	< 0.001
观察组	21	45.24±9.60	77.24±9.95	-13.185	< 0.001
t值		-0.318	-1.049
P值		0.753	0.301

组别	n	治疗前	治疗后	t值	P值
对照组	21	35.17±2.03	33.98±1.98	1.657	0.113
观察组	21	34.78±2.19	31.23±2.11	5.326	< 0.001
t值		0.583	4.365
P值		0.563	< 0.001

Effects of cerebellar theta-burst stimulation on lower extremity motor function in stroke patients

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