低频和高频重复经颅磁刺激对脑卒中后非流畅性失语的影响

doi:10.3969/j.issn.1006-9771.2023.03.001

Abstract

Abstract:

Objective To explore the effect of low frequency or high frequency repetitive transcranial magnetic stimulation (rTMS) on right Broca's homologue in stroke patients with nonfluent aphasia.

Methods From January, 2019 to August, 2022, 80 inpatients in Beijing Bo'ai Hospital were randomly divided into control group (n = 20), sham stimulation group (n = 20), low-frequency (1 Hz) rTMS (LF-rTMS) group (n = 20) and high-frequency (10 Hz) rTMS (HF-rTMS) group (n = 20). All the patients received routine language therapy. LF-rTMS group and HF-rTMS group received ten days of rTMS (1 Hz or 10 Hz), and the sham group received ten days of sham rTMS. The Western Aphasia Battery (WAB) was used to evaluate the language function before, after treatment, and two months after treatment.

Results Before treatment, there was no significant difference in the scores of WAB among four groups (P > 0.05). All the scores improved in the four groups immediately after treatment and two months after treatment (P < 0.05). Compared with immediately after treatment, all the scores of WAB improved in LF-rTMS group (P < 0.05), and the scores of recall, name and aphasia quotient (AQ) improved in HF-rTMS group (P < 0.05) two months after treatment. Immediately after treatment, the scores of content and fluency, auditory comprehension and AQ were higher in LF-rTMS group than in HF-rTMS group (P < 0.05). Two months after treatment, the scores of content and fluency were higher in LF-rTMS group than in HF-rTMS group (P < 0.05).

Conclusion Both 1 Hz and 10 Hz rTMS could improve the language function of stroke patients with nonfluent aphasia, especially 1 Hz.

Key words: stroke, nonfluent aphasia, repetitive transcranial magnetic stimulation, language function

CLC Number:

R743.3

HU Xueyan, JIANG Xiaofeng, SHAN Lei, YANG Lingyu, CHEN Yudong, MA Lin, LIU Lixu, ZHANG Tong. Effect of low frequency or high frequency repetitive transcranial magnetic stimulation on stroke patients with nonfluent aphasia[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(3): 249-255.

Figures/Tables 2

References 36

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组别	n	性别(男/女)/n	年龄/岁	发病时间/d	卒中类型(脑梗死/脑出血)/n	文化程度(小学/初中及以上)/n
对照组	20	14/6	56.83±11.22	35.39±11.40	10/10	5/15
假刺激组	20	14/6	58.58±9.35	36.47±12.15	12/8	4/16
低频组	20	15/5	52.72±11.80	37.00±11.50	11/9	5/15
高频组	20	13/7	54.50±11.20	32.33±10.54	11/9	4/16
F/χ²值		1.876	0.972	0.591	0.713	1.003
P值		0.509	0.411	0.623	0.887	0.317

项目	时间	对照组(n = 18)	假刺激组(n = 17)	低频组(n = 18)	高频组(n = 18)	F值	P值
自发言语	治疗前	2.85±1.84	3.03±2.04	3.39±1.71	2.62±2.01	0.515	0.673
	治疗结束时	3.90±1.93^a,d	4.51±2.59^a,d	8.83±4.47^d	4.43±3.46^a,d	11.221	< 0.001
	治疗结束2个月	6.16±3.32^a,d	7.41±3.62^d,e	9.67±3.61^d,e	7.05±4.29^a,d	3.048	0.035
听理解	治疗前	80.61±23.59	82.47±21.81	83.68±25.56	81.67±30.54	0.211	0.888
	治疗结束时	100.72±30.88^a,d	106.82±36.32^a,d	140.50±35.97^d	118.28±41.97^a,d	4.392	0.007
	治疗结束2个月	144.67±29.36^d	140.52±31.02^d,e	160.61±45.39^d,e	158.00±37.87^d	2.507	0.066
复述	治疗前	26.55±12.82	27.94±17.16	27.83±15.73	26.77±18.71	0.153	0.927
	治疗结束时	32.05±16.47^a,b,c,d	52.23±28.25^d	57.16±20.57^d	49.67±28.46^d	4.253	0.008
	治疗结束2个月	48.83±23.06^a,b,c,d	64.11±22.06^d,e	69.72±25.42^d,e	67.94±25.83^d,e	5.565	0.002
命名	治疗前	18.27±9.49	17.70±6.66	18.88±8.66	16.56±10.97	0.655	0.582
	治疗结束时	32.16±10.15^a,d	36.01±7.04^a,d	51.61±13.03^d	36.44±10.30^d	15.070	< 0.001
	治疗结束2个月	48.67±15.14^a,d	55.35±14.42^d,e	65.11±22.34^d,e	58.05±25.29^d,e	2.977	0.038
AQ	治疗前	24.06±7.75	24.74±9.39	26.49±7.63	25.60±16.27	0.326	0.807
	治疗结束时	34.65±14.71^a,d	37.62±13.35^a,d	56.21±16.99^d	42.01±18.68^a,d	8.281	< 0.001
	治疗结束2个月	47.05±18.12^a,b,d	52.65±12.08^d,e	64.82±19.51^d,e	59.37±15.29^d,e	2.878	0.042
F值_自发言语		13.148	7.776	10.583	7.575
P值_自发言语		< 0.001	0.001	< 0.001	0.001
F值_听理解		23.357	21.817	13.229	20.730
P值_听理解		< 0.001	< 0.001	< 0.001	< 0.001
F值_复述		20.037	12.048	19.962	7.313
P值_复述		< 0.001	< 0.001	< 0.001	0.002
F值_命名		20.037	18.941	36.779	23.633
P值_命名		< 0.001	< 0.001	< 0.001	< 0.001
F值_AQ		31.489	11.616	20.740	18.941
P值_AQ		< 0.001	< 0.001	< 0.001	< 0.001

Effect of low frequency or high frequency repetitive transcranial magnetic stimulation on stroke patients with nonfluent aphasia

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