经外耳皮肤迷走神经电刺激联合双侧上肢训练对脑卒中上肢运动功能的效果

doi:10.3969/j.issn.1006-9771.2023.03.006

Abstract

Abstract:

Objective To investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) combined with bilateral arm training (BAT) on upper limb motor function of hemiplegic stroke patients.

Methods From January, 2021 to January, 2022，105 stroke patients from Zhejiang Provincial People's Hospital were randomly divided into taVNS group (n = 35), BAT group (n = 35) and combined group (n = 35). All the patients received routine rehabilitation, while taVNS group received taVNS, BAT group received BAT, and the combined group received both taVNS and BAT, for eight weeks. The root mean square (RMS) of surface electromyography in deltoid, triceps brachii and extensor carpi was measured, and the scores of Box and Block Test (BBT), and Fugl-Meyer Assessment-Upper Extremities (FMA-UE) were obtained before and after treatment.

Results The RMS of all these muscles, and the scores of BBT and FMA-UE improved in all the three groups after treatment (|t| > 6.124, P< 0.001), and they were improved the most in the combined group (F > 18.162, P< 0.001).

Conclusion Both taVNS and BAT can enhance the muscle strength on the affected upper limb, increase the hand flexibility, and improve upper limb motor function of stroke patients, while the combination of both methods is more effective.

Key words: stroke, transcutaneous auricular vagus nerve stimulation, bilateral arm training, upper limb, motor function

CLC Number:

R743.3

ZHANG Xiaofeng, LIU Yong, JIN Zhenhua. Effect of transcutaneous auricular vagus nerve stimulation combined with bilateral arm training on upper limb motor function of stroke patients[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(3): 280-285.

Figures/Tables 6

References 39

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组别	n	性别(男/女)/n	年龄/岁	病程/d	偏瘫侧(左/右)/n	Brunnstrom分期 (Ⅰ/Ⅱ/Ⅲ/Ⅳ)/n
taVNS组	35	15/20	58.94±12.12	39.74±17.76	17/18	6/13/14/2
BAT组	35	18/17	56.60±13.23	38.69±15.01	15/20	4/15/12/4
联合组	35	19/16	57.63±13.72	42.20±18.66	21/14	7/12/15/1
χ²/F/H值		0.536	0.299	0.384	2.134	0.450
P值		0.765	0.742	0.682	0.344	0.799

组别	n	治疗前	治疗后	t值	P值
taVNS组	35	17.35±4.71	26.57±5.32	-7.676	< 0.001
BAT组	35	17.87±4.57	31.95±6.14	-10.438	< 0.001
联合组	35	16.94±5.19	35.63±1.24^a,b	-11.197	< 0.001
F值		0.327	18.162
P值		0.722	< 0.001

组别	n	治疗前	治疗后	t值	P值
taVNS组	35	9.22±2.64	23.32±4.15	-16.612	< 0.001
BAT组	35	9.17±2.48	26.32±4.87	-18.374	< 0.001
联合组	35	9.53±2.78	30.82±5.64^a,b	-20.443	< 0.001
F值		0.186	20.502
P值		0.830	< 0.001

组别	n	治疗前	治疗后	t值	P值
taVNS组	35	8.36±2.24	17.84±3.89	-12.447	< 0.001
BAT组	35	8.54±2.31	22.43±4.59	-16.512	< 0.001
联合组	35	8.81±2.43	27.78±44.86^a,b	-20.229	< 0.001
F值		0.347	43.410
P值		0.708	< 0.001

组别	n	治疗前	治疗后	t值	P值
taVNS组	35	3.74±1.88	12.54±4.26	-9.660	< 0.001
BAT组	35	3.86±1.68	15.34±4.14	-14.090	< 0.001
联合组	35	3.77±1.85	17.51±3.76^a,b	-220.657	< 0.001
F值		0.038	67.796
P值		0.963	< 0.001

Effect of transcutaneous auricular vagus nerve stimulation combined with bilateral arm training on upper limb motor function of stroke patients

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组别	n	治疗前	治疗后	t值	P值
taVNS组	35	25.23±4.52	32.37±5.92	-6.124	< 0.001
BAT组	35	24.95±4.82	39.53±5.24	-13.193	< 0.001
联合组	35	24.35±5.39	44.91±7.12^a,b	-15.777	< 0.001
F值		0.292	36.689
P值		0.747	< 0.001

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