神经反馈训练对老年人认知功能效果的系统综述

doi:10.3969/j.issn.1006-9771.2023.08.006

Abstract

Abstract:

Objective To systematically review the effect of neurofeedback training on cognitive function in the elderly within the framework of the International Classification of Diseases 11th Revision (ICD-11), and International Classification of Functioning, Disability and Health (ICF).
Methods A PICO framework was constructed. Randomized controlled trials on neurofeedback training for cognitive function in the elderly from PubMed, Web of Science, ProQuest, and CNKI up to July, 2023 were systematically reviewed. Methodological quality assessment of the included literature was performed using Physiotherapy Evidence Database scale.
Results A total of 15 researches were included, from ten countries, involving 520 participants, who were healthy elderly individuals or those with mild cognitive impairment. Various neurofeedback waveforms were utilized, such as alpha, beta, theta, beta/alpha, and sensorimotor rhythm (SMR) waves. Intervention duration ranged from 20 to 90 minutes, with intervention frequencies spanning from a long-term intervention of 30 sessions over 12 weeks to a high-frequency short-term intervention of eight sessions over one week. The primary health outcomes focused on cognitive function, including memory, attention, inhibitory control and executive function.
Conclusion Neurofeedback training can improve the cognitive function of the eldery, and alleviate cognitive aging.

Key words: neurofeedback, elderly, cognition, intervention, systematic review

CLC Number:

R493

JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.

Figures/Tables 4

纳入文献	国家	样本特征	神经反馈波形	持续时间	干预频率	对照组	比较	测试任务	结局指标
Alatorre-Cruz等^[7](2022)	墨西哥	MCI，n = 18，平均(68.60±5.95)岁	下调θ波	30 min	12周，共30次干预	虚假神经反馈干预	1.干预前后比较：干预后随访阶段执行功能得分显著高于干预前 2.干预组与对照组比较：干预组智力得分增长显著高于对照组	WAIS-Ⅲ NEUROPSI test	1.WAIS-Ⅲ中IQ得分显著提高; 2.执行功能显著改善
Becerra等^[8](2012)	墨西哥	MCI，n = 14，平均(65.8±2.4)岁	下调θ波	30 min	12周，共31次干预	虚假神经反馈干预	1.干预前后比较：干预后WAIS-Ⅲ中言语理解指数、言语智商得分显著提高，NEUROPSI test中记忆功能得分、总分显著提高 2.干预组与对照组比较：干预组全量表智商、言语理解指数得分增加显著高于对照组	WAIS-Ⅲ NEUROPSI test	1.WAIS-Ⅲ中言语理解指数、言语智商显著改善; 2.记忆功能显著改善
Bielas等^[9](2021)	波兰	健康人，n = 15，平均(72±7.02)岁	上调β波	20 min	2周，共20次干预	未接受干预	1.Stroop任务干预前后比较：干预后不一致条件下反应时显著降低，对照组前后测无显著差异 2.Simon任务干预前后比较：干预组不一致条件下反应时显著降低	Stroop任务 Simon任务	注意、抑制控制、执行功能显著改善
Campos da Paz等^[10](2018)	巴西	健康人，n = 17，平均(69.05±2.1)岁	控制SMR波	20 min	5周，共10次干预	虚假神经反馈干预/未接受干预	1.干预前后比较：干预后任务平均正确率显著提高，对照组前后测无显著性差异 2.干预组与对照组比较：干预组后测平均正确率显著高于对照组	DMTS	工作记忆显著改善
Gomez-Pilar等^[11](2016)	西班牙	健康人，n = 63，平均(68.0±5.6)岁	控制SMR波	30 min	5周，共5次干预	未接受干预	1.干预前后比较：干预后视觉感知、空间定向、接受性言语、表达性言语、即时记忆、逻辑记忆、主题绘画、概念活动得分显著提高 2.干预组与对照组比较：干预组视觉感知、即时记忆、概念活动得分增加显著高于对照组	Luria-AND test	视觉空间、口头语言、记忆、智力显著改善
Jirayucharoensak等^[12](2019)	泰国	MCI，n = 119，平均(71.7±6.5)岁	上调β/α波	20 min	12周，共20次干预	维持原治疗	1.干预前后比较：干预后延迟匹配任务、快速视觉信息处理得分显著提高 2.干预组与对照组比较：干预组快速视觉信息处理能力、空间工作记忆策略得分显著高于对照组	CANTAB	工作记忆显著改善、注意力显著改善
Lavy等^[13](2021)	以色列	MCI，n = 30，平均(70.23±6.65)岁	上调α波	30 min	8周，共10次干预	虚假神经反馈干预	1.干预前后比较：干预后综合记忆得分显著提高，对照组无显著变化	NeuroTrax^TM计算机认知评估测验	记忆功能改善
Marcos-Martínez等^[14](2021)	西班牙	健康人，n = 11，平均69.36岁	上调SMR波	90 min	5周，共5次干预	未接受干预	1.干预前后比较：干预后主题绘画、概念活动、接受性言语得分显著提高	Luria-AND test	口头言语、智力显著改善
Israsena等^[15](2021)	泰国	MCI，n = 65，平均(69.48±6.15)岁	上调α波	30 min	10周，共20次干预	虚假神经反馈干预	1.干预前后比较：干预后视觉记忆、注意力、空间工作记忆得分显著提高	CANTAB	记忆、注意功能显著改善
Reis等^[16](2016)	美国	健康人，n = 30，平均(65.97±6.63)岁	上调α波	30 min	1周，共8次干预	虚假神经反馈干预/认知训练干预	1.干预前后比较：神经反馈训练组矩阵旋转结果精度显著提高	DST MRT Stroop test TMT	空间记忆、注意力显著改善
Staufenbiel等^[17](2014)	荷兰	健康人，n = 20，平均(69.2±1.87)岁	上调β波	30 min	3周，共8次干预	上调γ波	1.干预前后比较：上调β组被试记忆测验得分显著提高，上调γ组被试无显著变化 2.不同干预方式比较：上调β波组被试训练后Raven's SPM得分显著高于上调γ组	Raven's SPM Memory任务	非言语智力、记忆显著改善
Lee等^[18](2015)	新加坡	健康人，n = 31，平均(65.1±2.9)岁	个性化调控	30 min	8周，共24次干预	虚假神经反馈干预	1.干预前后比较：干预后空间构造、注意、延迟记忆、总分显著提高	RBANS	注意、记忆显著改善
Lee等^[19](2013)	新加坡	健康人，n = 39，平均(65.2±2.8)岁	个性化调控	30 min	8周，共24次干预	未接受干预	1.干预前后比较：干预后延迟记忆得分显著增加、延迟记忆和注意得分中位数显著提高	RBANS	记忆、注意功能显著改善
Eijk等^[20](2017)	荷兰	健康人，n = 16，平均(77.9±7.8)岁	下调β波	21 min	9周，共10次干预	未接受干预	1.干预前后比较：干预后听觉语言学习测试即时回忆得分显著提高，对照组无显著变化	RAVLT	工作记忆能力显著改善
Wang等^[21](2013)	中国	健康人，n = 32，平均(65±3.3)岁	上调θ波	30 min	4周，共12次干预	虚假神经反馈干预	1.干预前后比较：干预后ANT得分显著提高;斯滕伯格识别任务得分显著提高	ANT 斯滕伯格识别任务	注意、抑制控制能力显著改善

References 25

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人群(Population)			干预 (Intervention)	比较 (Comparison)	结局 (Outcome)
健康状况	ICD-11编码	ICF编码	干预 (Intervention)	比较 (Comparison)	结局 (Outcome)
健康人 MCI患者年龄≥ 60岁	6E0Z神经认知障碍	主要功能障碍 b身体功能 b1精神功能 b117智力功能 b140注意力功能 b144记忆功能 b152情感功能 b160思维功能 b164高水平认知功能 b172计算功能	干预所选取的脑电波 β波 θ波 α波 β/α波 SMR波干预方案神经反馈训练单次持续时间神经反馈训练频率	1.神经反馈干预前后比较 2.神经反馈干预组与对照组比较 3.神经反馈干预方式比较	b140注意功能 b144记忆功能 b164执行功能

纳入文献	资格标准	随机分配	分配隐藏	基线均衡	被试施盲	治疗师施盲	评估者施盲	被试退出率≤ 15%	意向性分析	组间进行统计分析	点估计和变异性测量	总分
Alatorre-Cruz等^[7](2022)	√	√		√	√	√	√	√	√	√	√	9
Becerra等^[8](2012)	√	√		√	√			√	√	√	√	7
Bielas等^[9](2021)	√	√		√	√			√	√	√	√	7
Campos da Paz等^[10](2018)	√	√			√			√	√	√	√	6
Gomez-Pilar 等^[11](2016)	√	√	√	√	√			√	√	√	√	8
Jirayucharoensak等^[12](2019)	√	√			√			√	√	√	√	6
Lavy等^[13](2021)	√	√			√			√	√	√	√	6
Marcos-Martínez等^[14](2021)	√	√		√	√			√	√	√	√	7
Israsena等^[15](2021)	√	√	√	√	√			√	√	√	√	8
Reis等^[16](2016)	√	√	√		√			√	√	√	√	7
Staufenbiel等^[17](2014)	√	√	√	√	√	√	√	√	√	√	√	10
Lee等^[18](2015)	√	√			√	√	√	√	√	√	√	8
Lee等^[19](2013)	√	√			√	√	√	√	√	√	√	8
Eijk等^[20](2017)	√	√			√			√	√	√	√	6
Wang等^[21](2013)	√	√			√			√	√	√	√	6

Effect of neurofeedback training on cognitive function in the elderly: a systematic review

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