帕金森病伴冻结步态患者的运动功能和生活质量

doi:10.3969/j.issn.1006-9771.2024.03.012

Abstract

Abstract:

Objective To observe the differences in motor function and quality of life among mild-to-moderate Parkinson's disease (PD) patients with or without freezing of gait (FOG), and the correlation of FOG to motor function and quality of life.

Methods From April, 2021 to December, 2022, 132 mild-to-moderate PD patients aged 60 to 80 years were selected from Peking Union Medical College Hospital, and were divided into FOG group (n = 43) and non-FOG group (n = 89) according to the clinical features. They were assessed with Freezing of Gait Questionnaire (FOGQ), Berg Balance Scale (BBS), Timed "Up & Go" Test (TUGT), Five Times Sit to Stand Test (FTSST), isokinetic muscle strength, Unified Parkinson's Disease Rating Scale (UPDRS) and 39-item Parkinson's Disease Questionaire-39 (PDQ-39).

Results The BBS score was lower (Z = -2.354, P < 0.05), and the TUGT, FTSST, UPDRS part 2 and part 3 scores, and the Parkinson's disease summary index (PDSI) were higher in FOG group than in non-FOG group (Z > 3.074, t = 2.748, P < 0.01). FOGQ score correlated with BBS score, UPDRS Part 2 and Part 3 scores, and PDSI (|r| > 0.392, P < 0.001).

Conclusion FOG would impair motor function, activities of daily living and quality of life in mild-to-moderate PD patients, and increase the risk of falls.

Key words: Parkinson's disease, freezing of gait, motor, quality of life

CLC Number:

R742.5

GE Ying, ZHAO Wowa, ZHANG Lu, SHU Xuan, LI Jiawei, LIU Ying. Motor function and quality of life in Parkinson's disease patients with freezing of gait[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(3): 339-344.

Figures/Tables 3

Table 1

Table 2

Table 3

References 40

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变量	非冻结步态组(n = 89)	冻结步态组(n = 43)	t/Z值	P值
年龄/岁	68.72±7.00	69.78±5.90	-0.847	0.398
BBS评分	45 (42, 51)	43 (39, 48)	-2.354	0.019
TUGT/s	10.6 (8.5, 12.9)	13 (9.9, 18.0)	3.074	0.002
FTSST/s	11.7 (9.3, 15.1)	14.7 (11.8, 18.2)	3.457	0.001
膝屈曲最大峰值力矩/(N·m)	15.5 (11.3, 21.5)	12.5 (9.5, 20.5)	-1.649	0.099
膝伸展最大峰值力矩/(N·m)	32 (23, 39.5)	29.5 (19, 41)	-0.877	0.381
UPDRS第二部分评分	14 (10, 17.5)	19 (16, 25)	5.418	< 0.001
UPDRS第三部分评分	20.75±8.83	25.98±9.79	2.748	0.003

变量	非冻结步态组(n = 89)	冻结步态组(n = 43)	t/Z值	P值
PDSI	14.48 (8.34, 22.94)	29.11 (16.88, 39.79)	4.618	< 0.001
身体活动	10 (5, 37.5)	40 (22.5, 70)	4.681	< 0.001
ADL	4.17 (0, 16.67)	25 (12.5, 41.67)	4.835	< 0.001
精神健康	8.33 (0, 20.83)	20.83 (8.33, 41.67)	3.491	< 0.001
病耻感	12.5 (0, 37.5)	25 (0, 56.25)	1.482	0.138
社会支持	0 (0, 0)	0 (0, 25)	3.098	0.002
认知	18.75 (6.25, 31.25)	25 (12.5, 43.75)	2.751	0.006
交流	0 (0, 16.67)	16.67 (0, 41.67)	2.802	0.005
身体不适	33.33 (16.67, 41.67)	41.67 (16.67, 50)	1.821	0.069

自变量	未控制性别和年龄		控制性别和年龄
自变量	r值	P值	r值	P值
BBS评分	-0.466	< 0.001	-0.448	< 0.001
UPDRS第二部分评分	0.657	< 0.001	0.601	< 0.001
UPDRS第三部分评分	0.467	< 0.001	0.392	< 0.001
PDSI	0.641	< 0.001	0.560	< 0.001

Motor function and quality of life in Parkinson's disease patients with freezing of gait

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