经颅超声刺激在神经康复中应用的文献计量分析

doi:10.3969/j.issn.1006-9771.2024.12.007

Abstract

Abstract:

Objective To analyze the current status, research hotspots, and development trends of transcranial ultrasound stimulation (TUS) in neurorehabilitation.

Methods Relevant literature on the application of TUS in neurological rehabilitation was retrieved from CNKI, Wanfang data, and Web of Science Core Collection, covering publications from inception to December 31, 2023. VOSviewer 1.6.20 and CiteSpace 6.2.R1 were used for visualized analysis.

Results A total of 247 articles were included, with 124 in Chinese and 123 in English, showing an increasing trend in annual publications. The major contributors to English literature were China, the United States, Canada, France and South Korea. High-frequency Chinese keywords included transcranial ultrasound, neuromodulation, Parkinson's disease, stroke and clinical efficacy. The keyword clusters were transcranial ultrasound, neuromodulation, upper limb function and Parkinson's disease. Bursting keywords included rehabilitation, neural function, ultrasound therapy, closed-loop control and low intensity. High-frequency English keywords included focused ultrasound, deep brain stimulation, transcranial magnetic stimulation, blood-brain barrier and thalamotomy. Keyword clusters covered tissue plasminogen activator, ultrasonic imaging, transcranial magnetic stimulation, thalamotomy and ultrasound. Bursting keywords featured essential tremor, neurostimulation, direct current stimulation and transcranial ultrasound stimulation.

Conclusion Research on the application of TUS in neurorehabilitation is on the rise, focusing on its efficacy and safety in Parkinson's disease, essential tremor, and ischemic stroke. Future research needs to explore the mechanisms of TUS, optimize treatment plans, and promote the development of individualized therapies.

Key words: transcranial ultrasound stimulation, neurorehabilitation, bibliometrics

CLC Number:

R742

HE Huifang, GONG Xiang, WANG Xihui, ZHU Sisi, SHEN Ying. Application of transcranial ultrasound stimulation in neurorehabilitation: a bibliometric analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(12): 1420-1427.

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References 37

[1]	OSADA T, KONISHI S. Noninvasive intervention by transcranial ultrasound stimulation: modulation of neural circuits and its clinical perspectives[J]. Psychiatry Clin Neurosci, 2024, 78(5): 273-281.
[2]	吴毅. 经颅超声刺激在脑卒中后神经功能康复中的研究进展[J]. 中国康复医学杂志, 2024, 39(8): 1081-1083.
	WU Y. Research progress on transcranial ultrasound stimulation in neurological rehabilitation after stroke[J]. Chin J Rehabil Med, 2024, 39(8): 1081-1083.
[3]	ROSSI S, ANTAL A, BESTMANN S, et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines[J]. Clin Neurophysiol, 2021, 132(1): 269-306. doi: 10.1016/j.clinph.2020.10.003 pmid: 33243615
[4]	SREERAJ V S, ARUMUGHAM S S, VENKATASUBRAMANIAN G. Clinical practice guidelines for the use of transcranial direct current stimulation in psychiatry[J]. Indian J Psychiatry, 2023, 65(2): 289-296.
[5]	FOMENKO A, NEUDORFER C, DALLAPIAZZA R F, et al. Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications[J]. Brain Stimul, 2018, 11(6): 1209-1217. doi: S1935-861X(18)30296-1 pmid: 30166265
[6]	翟兆琳, 刘登堂. 经颅聚焦超声刺激治疗精神障碍的研究现状及展望[J]. 上海交通大学学报(医学版), 2021, 41(1): 95-98. doi: 10.3969/j.issn.1674-8115.2021.01.017
	ZHAI Z L, LIU D T. Research status and prospect of transcranial focused ultrasound stimulation in treatment of psychiatric disorders[J]. J Shanghai Jiao Tong Univ (Med Sci), 2021, 41(1): 95-98.
[7]	王卫宁, 梁思捷, 朱玉连. 经颅超声在脑部疾病中的应用研究进展[J]. 中国康复医学杂志, 2021, 36(1): 109-113.
[8]	QIN P P, JIN M, XIA A W, et al. The effectiveness and safety of low-intensity transcranial ultrasound stimulation: a systematic review of human and animal studies[J]. Neurosci Biobehav Rev, 2024, 156: 105501.
[9]	KRISHNA V, SAMMARTINO F, REZAI A. A review of the current therapies, challenges, and future directions of transcranial focused ultrasound technology: advances in diagnosis and treatment[J]. JAMA Neurol, 2018, 75(2): 246-254. doi: 10.1001/jamaneurol.2017.3129 pmid: 29228074
[10]	GLÄNZEL W, CZERWON H J. A new methodological approach to bibliographic coupling and its application to the national, regional and institutional level[J]. Scientometrics, 1996, 37(2): 195-221.
[11]	HAMEROFF S, TRAKAS M, DUFFIELD C, et al. Transcranial ultrasound (TUS) effects on mental states: a pilot study[J]. Brain Stimul, 2013, 6(3): 409-415. doi: 10.1016/j.brs.2012.05.002 pmid: 22664271
[12]	SHEN Y, ZHONG J G, LAN W T, et al. Bibliometric study of neuroinflammation in autism spectrum disorder[J]. Front Psychiatry, 2023, 14: 1086068.
[13]	袁毅, 陈玉东, 闫佳庆, 等. 经颅霍尔效应刺激作用下神经元系统放电节律的理论研究[J]. 中国生物医学工程学报, 2016, 35(2): 247-251.
	YUAN Y, CHEN Y D, YAN J Q, et al. Theoretical study of firing rhythm of neuron system based on transcranial hall-effect stimulation[J]. Chin J Biomed Eng, 2016, 35(2): 247-251.
[14]	WATTIEZ N, CONSTANS C, DEFFIEUX T, et al. Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task[J]. Brain Stimul, 2017, 10(6): 1024-1031. doi: S1935-861X(17)30847-1 pmid: 28789857
[15]	VERHAGEN L, GALLEA C, FOLLONI D, et al. Offline impact of transcranial focused ultrasound on cortical activation in primates[J]. eLife, 2019, 8: e40541.
[16]	LEGON W, SATO T F, OPITZ A, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans[J]. Nat Neurosci, 2014, 17(2): 322-329. doi: 10.1038/nn.3620 pmid: 24413698
[17]	LEGON W, BANSAL P, TYSHYNSKY R, et al. Transcranial focused ultrasound neuromodulation of the human primary motor cortex[J]. Sci Rep, 2018, 8(1): 10007. doi: 10.1038/s41598-018-28320-1 pmid: 29968768
[18]	AI L, BANSAL P, MUELLER J K, et al. Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study[J]. BMC Neurosci, 2018, 19(1): 56. doi: 10.1186/s12868-018-0456-6 pmid: 30217150
[19]	MUELLER J, LEGON W, OPITZ A, et al. Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics[J]. Brain Stimul, 2014, 7(6): 900-908. doi: 10.1016/j.brs.2014.08.008 pmid: 25265863
[20]	LEGON W, ADAMS S, BANSAL P, et al. A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans[J]. Sci Rep, 2020, 10(1): 5573. doi: 10.1038/s41598-020-62265-8 pmid: 32221350
[21]	DARMANI G, BERGMANN T O, BUTTS PAULY K, et al. Non-invasive transcranial ultrasound stimulation for neuromodulation[J]. Clin Neurophysiol, 2022, 135: 51-73.
[22]	GIBB W R, LEES A J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 1988, 51(6): 745-752.
[23]	李春婵, 杨佳佳, 刘近贞, 等. 经颅超声在帕金森病治疗中的应用[J]. 生物化学与生物物理进展, 2023, 50(1): 25-37.
	LI C C, YANG J J, LIU J Z, et al. The application of transcranial ultrasound in the treatment of Parkinson's disease[J]. Prog Biochem Biophys, 2023, 50(1): 25-37.
[24]	MAGARA A, BÜHLER R, MOSER D, et al. First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease[J]. J Ther Ultrasound, 2014, 2: 11.
[25]	BOND A E, SHAH B B, HUSS D S, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease: a randomized clinical trial[J]. JAMA Neurol, 2017, 74(12): 1412-1418. doi: 10.1001/jamaneurol.2017.3098 pmid: 29084313
[26]	ZAAROOR M, SINAI A, GOLDSHER D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson's disease and essential tremor cases[J]. J Neurosurg, 2018, 128(1): 202-210. doi: 10.3171/2016.10.JNS16758 pmid: 28298022
[27]	GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet Neurol, 2021, 20(10): 795-820.
[28]	GUO J, LO W L A, HU H, et al. Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: a review[J]. Front Neurosci, 2022, 16: 964060.
[29]	ZHU S, MENG B, JIANG J, et al. The updated role of transcranial ultrasound neuromodulation in ischemic stroke: from clinical and basic research[J]. Front Cell Neurosci, 2022, 16: 839023.
[30]	刘婧, 刘子渤, 李红玲. 经颅超声刺激辅助缺血性脑卒中后康复训练的研究进展[J]. 中华物理医学与康复杂志, 2021, 43(3): 268-272.
[31]	ISHIBASHI T, AKIYAMA M, ONOUE H, et al. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator[J]. Stroke, 2002, 33(5): 1399-1404.
[32]	席悦, 郭方圆, 晏光林, 等. 经颅超声刺激对脑卒中患者上肢功能恢复及皮质兴奋性的影响[J]. 华西医学, 2023, 38(6): 828-834.
	XI Y, GUO F Y, YAN G L, et al. Effect of transcranial ultrasound stimulation on upper limb function recovery and cortical excitability in patients with stroke[J]. West Chin Med J, 2023, 38(6): 828-834.
[33]	LEE W, CHUNG Y A, JUNG Y, et al. Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound[J]. BMC Neurosci, 2016, 17(1): 68. pmid: 27784293
[34]	LOUIS E D, FERREIRA J J. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor[J]. Mov Disord, 2010, 25(5): 534-541.
[35]	BENABID A L, POLLAK P, GERVASON C, et al. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus[J]. Lancet, 1991, 337(8738): 403-406. doi: 10.1016/0140-6736(91)91175-t pmid: 1671433
[36]	WINTERMARK M, DRUZGAL J, HUSS D S, et al. Imaging findings in MR imaging-guided focused ultrasound treatment for patients with essential tremor[J]. AJNR Am J Neuroradiol, 2014, 35(5): 891-896.
[37]	ELIAS W J, LIPSMAN N, ONDO W G, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor[J]. N Engl J Med, 2016, 375(8): 730-739.

国家	发文量/n	被引频次	平均被引频次
中国	39	708	18.15
美国	35	1417	40.49
加拿大	11	376	34.18
法国	10	415	41.50
韩国	10	346	34.60

排名	中文文献		英文文献
排名	机构	发文量 /n	机构	发文量 /n
1	燕山大学	22	University of Toronto	9
2	上海交通大学	5	Yanshan University	5
3	河北工业大学	5	Chinese Academy of Sciences	4
4	中国科学院大学	4	Guangdong University of Technology	4
5	复旦大学	4	Medical University of Vienna	4

排名	中文文献		英文文献
排名	作者	发文量/n	作者	发文量/n
1	陈玉东	3	Aubry Jean-Francois	5
2	杨悦凡	2	Yuan Yi	3
3	殷尚炯	2	Beisteiner Roland	3
4	王丽丽	2	Chen Yan	3
5	王健	2	He Jiaru	3

Application of transcranial ultrasound stimulation in neurorehabilitation: a bibliometric analysis

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排名	中文文献		英文文献
排名	关键词	频次	关键词	频次
1	经颅超声	16	focused ultrasound	31
2	神经调控	15	deep brain stimulation	21
3	脑卒中	10	stimulation	21
4	帕金森病	6	transcranial magnetic stimulation	20
5	临床疗效	2	brain stimulation	17
6	康复	2	transcranial focused ultrasound	15
7	闭环控制	2	blood brain barrier	9
8	光遗传学	2	neuromodulation	8
9	超声治疗	2	noninvasive brain stimulation	8
10	脑梗死	2	thalamotomy	7

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