卒中后失语患者汉语词图匹配任务态脑电的时域及时频特征

doi:10.3969/j.issn.1006-9771.2025.08.011

Abstract

Abstract:

Objective To explore characteristics of time-domain and time-frequency of task-related electroencephalogram (EEG) in patients with post-stroke aphasia (PSA).

Methods From January, 2018 to December, 2021, 18 PSA patients (PSA group) were recruited from Dongzhimen Hospital, Beijing University of Chinese Medicine, and nine healthy subjects (control group) were recruited with matched gender, age and education level. EEG data based on the Chinese word-picture matching task were collected, and the average amplitude of N400 and event-related synchronization (ERS) /desynchronization (ERD) were analyzed. The PSA group was assessed with Chinese Rehabilitation Research Center Aphasia Examination (CRRCAE).

Results The effect of N400 was significant on left frontal, central frontal, right frontal, left central and central areas. The average amplitude of N400 was higher on the frontal area in PSA group than in the control group, and it was lower on right temporal-parietal area. For word-picture mismatching, average amplitude of N400 at FPZ was moderately correlated with auditory comprehension (r = 0.483, P < 0.05), the average amplitude of N400 at T8 was moderately correlated with repetition (r = 0.584, P < 0.05) and reading aloud (r = 0.556, P < 0.05), and the average amplitude of N400 at P6 was moderately correlated with speaking (r = 0.476, P < 0.05) and reading (r = 0.502, P < 0.05). For word-picture matching, the average amplitude of N400 at P7 was moderately negatively correlated with calculation (r = -0.481, P < 0.05). Compared with the control group, the energy decreased in θ and α frequency bands with absence of ERS in PSA group, and it increased in β frequency band with absence of ERD.

Conclusion The activities of Chinese word-picture matching task-related EEG have been inhibited on right temporal-parietal area for PSA patients, and it compensatively increases on frontal area, while the energy decreases in θ and α frequency bands with ERS deficiency, and increases in β frequency band with ERD deficiency.

Key words: post-stroke aphasia, Chinese word-picture matching task, electroencephalography, event-related potential

ZHANG Zihan, GUAN Jinzhi, HUANG Xing, ZHOU Li, ZHANG Yaxuan, ZHANG Mengyuan, CHANG Jingling. Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 947-957.

Figures/Tables 9

Table 1

Figure 1

Table 2

Figure 2

Table 3

Figure 3

Figure 4

Figure 5

Figure 6

References 43

[1]	GRÖNBERG A, HENRIKSSON I, STENMAN M, et al. Incidence of aphasia in ischemic stroke[J]. Neuroepidemiology, 2022, 56(3): 174-182.
[2]	SHEPPARD S M, SEBASTIAN R. Diagnosing and managing post-stroke aphasia[J]. Expert Rev Neurother, 2021, 21(2): 221-234. doi: 10.1080/14737175.2020.1855976 pmid: 33231117
[3]	WU C, QIN Y, LIN Z, et al. Prevalence and impact of aphasia among patients admitted with acute ischemic stroke[J]. J Stroke Cerebrovasc Dis, 2020, 29(5): 104764.
[4]	中华医学会神经病学分会神经康复学组, 中国康复医学会脑血管病专业委员会, 中国康复研究中心. 卒中后失语临床管理专家共识[J]. 中国康复理论与实践, 2022, 28(1): 15-23. doi: 10.3969/j.issn.1006-9771.2022.01.003
	Neurologic Rehabilitation Studies Group of Neurology Branch of Chinese Medical Association, Cerebrovascular Diseases Committee of Chinese Association Rehabilitation Medicine, China Rehabilitation Research Centre. Consensus on clinical management of post-stroke aphasia[J]. Chin J Rehabil Theory Pract, 2022, 28(1): 15-23.
[5]	DAN Y, CAI A, MA J, et al. A novel approach for aphasia evaluation based on ROI-based features from structural magnetic resonance image[J]. IEEE J Biomed Health Inform, 2025, 29(4): 2772-2783.
[6]	BEPPI C, RIBEIRO VIOLANTE I, SCOTT G, et al. EEG, MEG and neuromodulatory approaches to explore cognition: current status and future directions[J]. Brain Cogn, 2021, 148(4950): 105677.
[7]	GRAESSNER A, DUCHOW C, ZACCARELLA E, et al. Electrophysiological correlates of basic semantic composition in people with aphasia[J]. Neuroimage Clin, 2023, 40: 103516.
[8]	ARAKI T, WATANABE Y, HIRATA M. Left hemispheric α band cerebral oscillatory changes correlate with verbal memory[J]. Sci Rep, 2020, 10(1): 14993. doi: 10.1038/s41598-020-72087-3 pmid: 32929146
[9]	樊瑞文, 史华伟, 黄幸, 等. 工作记忆与词汇学习:基于词图匹配任务的事件相关电位研究[J]. 中国康复理论与实践, 2019, 25(1): 70-75. doi: 10.3969/j.issn.1006-9771.2019.00.001
	FAN R W, SHI H W, HUANG X, et al. Role of working memory in lexical access: an event-related potential study based on word-picture matching tasks[J]. Chin J Rehabil Theory Pract, 2019, 25(1): 70-75.
[10]	中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国各类主要脑血管病诊断要点2019[J]. 中华神经科杂志, 2019, 52(9): 710-715.
	Chinese Society of Neurology, Chinese Stroke Society. Diagnostic criteria of cerebrovascular diseases in China (version 2019)[J]. Chin J Neurol, 2019, 52(9): 710-715.
[11]	常静玲, 张斌龙, 谭中建, 等. 基于汉语高频名词下词图匹配语义判断任务的设计与运用范式[J]. 中国康复理论与实践, 2018, 24(8): 917-923. doi: 10.3969/j.issn.1006-9771.2018.08.010
	CHANG J L, ZHANG B L, TAN Z J, et al. Design and pilot study of word-picture matching semantic judgment task based on Chinese high frequency nouns[J]. Chin J Rehabil Theory Pract, 2018, 24(8): 917-923.
[12]	DELORME A, MAKEIG S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis[J]. J Neurosci Methods, 2004, 134(1): 9-21.
[13]	黄幸, 常静玲, 张梓寒, 等. 卒中后失语工作记忆的事件相关电位及时频特征[J]. 中国康复理论与实践, 2024, 30(3): 316-325. doi: 10.3969/j.issn.1006-9771.2024.03.009
	HUANG X, CHANG J L, ZHANG Z H, et al. Characteristics of event-related potential and frequency on working memory of post-stroke aphasia[J]. Chin J Rehabil Theory Pract, 2024, 30(3): 316-325.
[14]	STALPAERT J, STANDAERT S, D'HELFT L, et al. Therapy-induced electrophysiological changes in primary progressive aphasia: a preliminary study[J]. Front Hum Neurosci, 2022, 16: 766866.
[15]	张梦龙, 卓碧芳, 秦晨阳, 等. 失语症常用评价方法及其信效度概况[J]. 吉林中医药, 2022, 42(3): 366-369.
	ZHANG M L, ZHUO B F, QIN C Y, et al. Application, reliability and validity of common evaluation methods for aphasia[J]. Jilin J Chin Med, 2022, 42(3): 366-369.
[16]	苑梓楠, 李思奇, 陈心雅, 等. 卒中后运动性失语症患者的语言损伤特点分析[J]. 中国卒中杂志, 2023, 18(11): 1238-1247.
	YUAN Z N, LI S Q, CHEN X Y, et al. Analysis of language impairment characteristics in patients with post-stroke Broca's aphasia[J]. Chin J Stroke, 2023, 18(11): 1238-1247. doi: 10.3969/j.issn.1673-5765.2023.11.004
[17]	DURFEE A Z, HARNISH S M. Using word-picture verification to inform language impairment locus in chronic post-stroke aphasia[J]. Front Rehabil Sci, 2022, 3: 1012588.
[18]	DIRANI J, PYLKKÄNEN L. The time course of cross-modal representations of conceptual categories[J]. Neuroimage, 2023, 277: 120254.
[19]	燕浩, 黄莹颖, 董洁. 音、形、义在词汇语义通达过程中的交互激活机制[J]. 外语教学, 2023, 44(6): 16-20.
	YAN H, HUANG Y Y, DONG J. Mutual activation of phonological, orthographic and semantic information in semantic access[J]. Foreign Lang Educ, 2023, 44(6): 16-20.
[20]	樊瑞文, 常静玲. 脑卒中后失语事件相关电位N400语言任务范式探讨[J]. 中国康复医学杂志, 2018, 33(7): 869-873.
	FAN R W, CHANG J L. Discussion on N400 language task paradigm of aphasia event related potential after stroke[J]. Chin J Rehabil Med, 2018, 33(7): 869-873.
[21]	GUO W, GENG S, CAO M, et al. The brain connectome for Chinese reading[J]. Neurosci Bull, 2022, 38(9): 1097-1113. doi: 10.1007/s12264-022-00864-3 pmid: 35575936
[22]	CATRICALÀ E, POLITO C, PRESOTTO L, et al. Neural correlates of naming errors across different neurodegenerative diseases: an FDG-PET study[J]. Neurology, 2020, 95(20): e2816-e2830.
[23]	STEFANIAK J D, GERANMAYEH F, LAMBON RALPH M A. The multidimensional nature of aphasia recovery post-stroke[J]. Brain, 2022, 145(4): 1354-1367. doi: 10.1093/brain/awab377 pmid: 35265968
[24]	MENON V, D'ESPOSITO M. The role of PFC networks in cognitive control and executive function[J]. Neuropsychopharmacology, 2022, 47(1): 90-103.
[25]	VOGEL P, HAHN J, DUVARCI S, et al. Prefrontal pyramidal neurons are critical for all phases of working memory[J]. Cell Rep, 2022, 39(2): 110659.
[26]	VILLAR-RODRÍGUEZ E, CANO-MELLE C, MARIN-MARIN L, et al. What happens to the inhibitory control functions of the right inferior frontal cortex when this area is dominant for language?[J]. Elife, 2024, 12: RP86797.
[27]	MESULAM M M. Temporopolar regions of the human brain[J]. Brain, 2023, 146(1): 20-41.
[28]	HOLROYD C B. The controllosphere: the neural origin of cognitive effort[J]. Psychol Rev, 2025, 132(3): 603-631.
[29]	SINGHAL S, GHOSH P, KUMAR N, et al. Parametric separation of phase-locked and non-phase-locked activity[J]. J Neurophysiol, 2023, 129(1): 199-210.
[30]	王仲朋, 刘佳, 陈龙, 等. 脑电标志物在意识障碍评估中的应用[J]. 生物化学与生物物理进展, 2025, 52(4): 899-914.
	WANG Z P, LIU J, CHEN L, et al. Applications of EEG biomarkers in the assessment of disorders of consciousness[J]. Prog Biochem Biophys, 2025, 52(4): 899-914.
[31]	ZHANG H, ZHOU Q Q, CHEN H, et al. The applied principles of EEG analysis methods in neuroscience and clinical neurology[J]. Mil Med Res, 2023, 10(1): 67. doi: 10.1186/s40779-023-00502-7 pmid: 38115158
[32]	REKTOR I, SOCHŮRKOVÁ D, BOCKOVÁ M. Intracerebral ERD/ERS in voluntary movement and in cognitive visuomotor task[J]. Prog Brain Res, 2006, 159: 311-330.
[33]	RATCLIFFE O, SHAPIRO K, STARESINA B P. Fronto-medial theta coordinates posterior maintenance of working memory content[J]. Curr Biol, 2022, 32(10): 2121-2129. e3.
[34]	ALBOUY P, MARTINEZ-MORENO Z E, HOYER R S, et al. Supramodality of neural entrainment: rhythmic visual stimulation causally enhances auditory working memory performance[J]. Sci Adv, 2022, 8(8): eabj9782.
[35]	MCLOUGHLIN G, GYURKOVICS M, PALMER J, et al. Midfrontal theta activity in psychiatric illness: an index of cognitive vulnerabilities across disorders[J]. Biol Psychiatry, 2022, 91(2): 173-182.
[36]	樊瑞文, 黄幸, 李晓琳, 等. 卒中后失语非损伤侧脑电功率谱网络特征研究[J]. 中国康复理论与实践, 2020, 26(6): 692-696. doi: 10.3969/j.issn.1006-9771.2020.06.013
	FAN R W, HUANG X, LI X L, et al. Characteristics of electroencephalogram power spectrum network on uninjured side of post-stroke aphasia[J]. Chin J Rehabil Theory Pract, 2020, 26(6): 692-696.
[37]	LUGTMEIJER S, LAMMERS N A, DE HAAN E H F, et al. Post-stroke working memory dysfunction: a meta-analysis and systematic review[J]. Neuropsychol Rev, 2021, 31(1): 202-219. doi: 10.1007/s11065-020-09462-4 pmid: 33230717
[38]	MORROW A, ELIAS M, SAMAHA J. Evaluating the evidence for the functional inhibition account of alpha-band oscillations during preparatory attention[J]. J Cogn Neurosci, 2023, 35(8): 1195-1211.
[39]	ZHAO M, HU G, LU Y, et al. Association between electroencephalogram alpha-band oscillations and executive and processing functions in patients with cerebral small vessel diseases[J]. J Cereb Blood Flow Metab, 2024, 44(11): 1302-1315.
[40]	LU Y, MAO L, WANG P, et al. Aberrant neural oscillations in poststroke aphasia[J]. Psychophysiology, 2024, 61(11): e14655
[41]	HE S, BAIG F, MERLA A, et al. Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease[J]. Brain, 2023, 146(12): 5015-5030. doi: 10.1093/brain/awad233 pmid: 37433037
[42]	ADHAM A, LE B T, BONNAL J, et al. Neural basis of lower-limb visual feedback therapy: an EEG study in healthy subjects[J]. J Neuroeng Rehabil, 2024, 21(1): 114. doi: 10.1186/s12984-024-01408-8 pmid: 38978051
[43]	GASTALDON S, ARCARA G, NAVARRETE E, et al. Commonalities in alpha and beta neural desynchronizations during prediction in language comprehension and production[J]. Cortex, 2020, 33: 328-345.

组别	性别(男/女)/n	年龄/岁	受教育年限/年
对照组	6/3	52.00±5.60	12.00(7.5，12.0)
PSA组	13/5	54.45±10.18	12.00(11.3，16.0)
t/Z值	-	0.652	-1.457
P值	1.000	0.521	0.145

分项	评分
听理解	25.94±11.41
复述	19.00±8.87
说	11.83±11.96
出声读	14.72±9.89
阅读	25.72±10.69
抄写	6.89±4.90
描写	6.61±8.60
听写	4.22±5.47
计算	10.22±5.64

条件	电极	电极定位	对照组(n = 9)	PSA组(n = 18)	t值	P值
词图匹配	AF3	左前额区	0.84±1.60	-1.56±3.11	-2.166	0.040
	CP4	右中央顶区	-0.36±0.82	0.58±1.05	2.348	0.027
	P7	左顶区	-0.48±1.11	1.21±1.68	2.705	0.012
词图不匹配	FP1	左前额区	0.20±1.58	-1.48±2.15	-2.075	0.048
	FPZ	前额区	-0.55±1.24	-2.06±1.97	-2.080	0.048
	FP2	右前额区	0.44±1.70	-1.17±1.45	-2.562	0.017
	T8	右颞区	-1.39±1.18	0.16±1.71	2.430	0.023
	P6	右顶区	-0.37±1.02	1.10±1.13	3.314	0.003
	P7	左顶区	-0.10±1.25	1.22±1.47	2.298	0.030

Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 9

References 43

Related Articles 15

Metrics

Comments

Recommended 0

[1]	LI Qiaozhen, FENG Feng, DU Xia, SHAO Wen, GAO Mi, HUI Linna, YUAN Hua, SUN Xiaolong. Characteristics of electroencephalography in neuropathic pain after spinal cord injury [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 830-837.
[2]	ZHANG Zhe, DONG Xianwen, XU Chengming, HU Wenjing, HE Tingli, CUI Xinxin, XU Hongyan, ZHOU Zhangying, HAN Ya'nan. Electroencephalography applied in autism spectrum disorder research in decade: a bibliometrics analysis [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(6): 693-700.
[3]	HUANG Xing, CHANG Jingling, ZHANG Zihan, LI Ying. Characteristics of event-related potential and frequency on working memory of post-stroke aphasia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(3): 316-325.
[4]	MA Xiaochen, LI Shufan, JIA Shuqi, LIU Cong, ZHANG Zhenyu, HAN Dongyang. Relationship of physical activity and cognitive function to sleep quality in older adults with cognitive impairment: a mediating effect of resting EEG [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(12): 1442-1451.
[5]	CHEN Yu, GUO Feng, GUO Jianrui, DONG Tongtong, XIA Xuelian. Activation characteristics of motor cortex during mirror visual feedback based on electroencephalography [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 967-976.
[6]	GUO Feng,HAO Ying,CHEN Yu. Brain sources characteristics during movement of residual limbs in forearm amputees based on standard low resolution brain electromagnetic tomography technology [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(8): 972-980.
[7]	ZHOU Yufan,XU Minjie,TAN Yihai,MA Ya'nan,REN Qiaosheng,CHEN Jian,ZHANG Qingsu,WANG Bo,HE Yi,CHANG Jingling. Characteristics of post-stroke aphasia structural damage based on structural covariance network [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(10): 1198-1204.
[8]	ZHAO Jing,LIU Xiaobo,LI Juan,ZHENG Zhong,JIN Rongjiang. Event-related potential for cognitive function research: a visual analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 69-78.
[9]	LIU Shaowen,WEI Conghui,SHAN Xinying,ZHANG Yan. Brain functional connectivity in lower limb amputees [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 90-94.
[10]	ZHANG Xiao-tong,LI Na,CHEN Zhao-cong,LIANG Jing-feng,YU Yong,WU Hui-xiang,KANG Zhuang,QIU Wei-hong. Potential Role of Right Cerebellum in Post-stroke Aphasia: A Preliminary Study Based on Granger Causality Analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1458-1463.
[11]	SHU Xin,DONG Xing-lu,HAO Xiao-hui,WEI Dong-jie,HUANG Xing,LI Xiao-lin,XU Min-jie,LI Chang-ming,KONG Qiao,HUANG Jia-qin,LIU Meng-yu,CHANG Jing-ling. Development of A Patient-reported Outcomes Scale for Post-stroke Aphasia Based on Traditional Chinese Medicine Holism [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(11): 1356-1364.
[12]	SUN Xiao-qin,FENG Ying,XIAO Nong. Advance in P300 Wave for Prognosis of Consciousness Disorders (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(7): 784-787.
[13]	LI Xiao-lin,ZHANG Bin-long,FAN Rui-wen,XU Min-jie,HUANG Xing,SHU Xin,LI Chang-ming,TAN Zhong-jian,CHANG Jing-ling. Stimulation Mode and Model of Word-picture Language Task in Functional Magnetic Resonance Imaging Test for Post-stroke Aphasia (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 668-672.
[14]	DU Yu-peng,LI Xiao-dong,LIU Wen-bing,LIU Xue-yun. Intensities of Transcranial Direct Current Stimulation for Dysphagia after Cerebral Infarction [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 583-587.
[15]	AN Wen-jun, LI Jin-hua, WANG He-ping. Advance in Electroencephalographic and Imaging Studies in Depression Children and Adolescents (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 314-318.