汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析

doi:10.3969/j.issn.1006-9771.2025.09.005

Abstract

Abstract:

Objective To examine resting-state whole-brain network connectivity in children with Chinese developmental dyslexia (DD) and typically developing (TD) children using functional near-infrared spectroscopy (fNIRS).

Methods From November to December, 2024, 19 DD children aged six to twelve years in Children's Hospital of Fudan University were enrolled, along with 18 TD children matching age and sex. Regions of interest included frontal cortex (FC), temporal lobe (TL), occipital lobe (OL) and parietal lobe (PL). Resting-state data were acquired by fNIRS for five minutes in both groups. Functional connectivity strength was calculated at rest, and between-group differences in connectivity strength and brain networks were compared, based on the time series of oxyhemoglobin concentration.

Results The whole-brain functional connectivity strength was higher in DD group than in TD group (t = 2.100, P< 0.05). Connectivity between the right OL-right FC (t = 2.426, P< 0.05), right OL-left FC (t = 2.483, P < 0.05), right TL-right FC (t = 2.568, P < 0.05) and right TL-left FC (t = 2.304, P < 0.05) were stonger in DD group than in TD group. The major regions exhibiting differences of whole-brain connectivity between two groups were the right dorsolateral prefrontal cortex, right visual association cortex, right frontal cortex, left orbitofrontal cortex, left visual association cortex, left primary visual cortex and right primary motor cortex.

Conclusion Children with DD exhibited significantly stronger connectivity in the right occipital and temporal lobes, as well as between these regions and the prefrontal cortex, suggesting possible right-hemispheric compensation for insufficiency in the left-hemisphere reading network.

Key words: developmental dyslexia, functional near-infrared spectroscopy, resting state, whole-brain functional connectivity

CLC Number:

R749.93

LUO Dandan, SHEN Min, WANG Sujuan, QIU Wengxin, ZHANG Yuxuan, WU Yun, WANG Shengxiao. Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dyslexia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1023-1031.

Figures/Tables 8

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组别	n	性别(男/女)/n	年龄/岁	韦氏IQ
TD组	18	11/7	8.50±1.72	107.88±11.66
DD组	19	12/7	8.31±1.41	100.42±12.43
χ²/t值		0.016	0.356	1.882
P值		0.898	0.724	0.068

ROI	通道排布
左侧FC	CH23、CH22、CH20、CH8、CH10、CH9、CH24
右侧FC	CH19、CH17、CH5、CH7、CH6、CH21
左侧TL	CH33、CH32、CH26、CH27、CH25、CH12、CH11
右侧TL	CH34、CH35、CH2、CH1、CH18、CH4、CH3
左侧PL	CH44、CH31、CH14、CH43、CH30、CH13
右侧PL	CH42、CH16、CH29、CH45、CH15、CH28
左侧OL	CH39、CH40、CH41、CH47、CH48
右侧OL	CH38、CH37、CH36、CH46

ROI	TD组	DD组	t值	P值
右侧OL-右侧FC	0.11	0.28	2.426	0.020
右侧OL-左侧FC	0.08	0.26	2.483	0.017
右侧TL-右侧FC	0.24	0.39	2.568	0.014
右侧TL-左侧FC	0.22	0.33	2.304	0.027

通道	连接通道数	依据 MNI坐标映射脑区分布
CH17	18	右侧背外侧前额叶皮质
CH46	12	右侧视觉联合皮质
CH5	12	右侧额叶皮质
CH8	9	左侧额眶区
CH47	8	左侧视觉联合皮质
CH40	7	左侧初级视觉皮质
CH1	7	右侧初级皮质运动区
CH37	4	右侧初级视觉皮质
CH20	2	左侧额极区
CH30	2	左侧初级躯体感觉皮质
CH36	2	右侧视觉联合皮质

Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dyslexia

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