Chinese Journal of Rehabilitation Theory and Practice ›› 2025, Vol. 31 ›› Issue (11): 1265-1270.doi: 10.3969/j.issn.1006-9771.2025.11.003
Previous Articles Next Articles
HE Aiqun(
), LI Jingbo, LIU Hai'ou, SONG Qiushuang, HE Maoli, LIN Rumin
Received:2025-08-07
Revised:2025-10-07
Published:2025-11-25
Online:2025-11-26
Contact:
HE Aiqun
E-mail:haq0101@126.com
Supported by:CLC Number:
HE Aiqun, LI Jingbo, LIU Hai'ou, SONG Qiushuang, HE Maoli, LIN Rumin. Effect of bilateral upper limb training after priming upper limb robot training on upper limb function in stroke patients with severe hemiplegia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(11): 1265-1270.
Table 1
Comparison of baseline data between two groups"
| 组别 | n | 性别(男/女)/n | 年龄/岁 | 病程/d | 卒中类型(出血/梗死)/n | 偏瘫侧(左/右)/n | 利手(左/右)/n |
|---|---|---|---|---|---|---|---|
| 对照组 | 30 | 18/12 | 55.90±11.66 | 50.57±21.83 | 13/17 | 11/19 | 0/30 |
| 试验组 | 30 | 21/9 | 51.80±13.06 | 44.93±24.43 | 10/20 | 10/20 | 1/29 |
| χ2/t值 | 0.659 | 0.652 | 0.871 | 0.635 | 0.073 | ||
| P值 | 0.417 | 0.205 | 0.350 | 0.426 | 0.787 | 0.500a | |
| [1] |
FEIGIN V L, STARK B A, JOHNSON C O, et al. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet Neurol, 2021, 20(10): 795-820.
doi: 10.1016/S1474-4422(21)00252-0 pmid: 34487721 |
| [2] |
ANGERHÖFER C, COLUCCI A, VERMEHREN M, et al. Post-stroke rehabilitation of severe upper limb paresis in Germany: toward long-term treatment with brain-computer interfaces[J]. Front Neurol, 2021, 12: 772199.
doi: 10.3389/fneur.2021.772199 |
| [3] |
MAIER M, BALLESTER B R, VERSCHURE P F M J. Principles of neurorehabilitation after stroke based on motor learning and brain plasticity mechanisms[J]. Front Syst Neurosci, 2019, 13: 74.
doi: 10.3389/fnsys.2019.00074 pmid: 31920570 |
| [4] |
YAN W, LIN Y, CHEN Y F, et al. Enhancing neuroplasticity for post-stroke motor recovery: mechanisms, models, and neurotechnology[J]. IEEE Trans Neural Syst Rehabil Eng, 2025, 33: 1156-1168.
doi: 10.1109/TNSRE.2025.3551753 |
| [5] |
STOYKOV M E, MADHAVAN S. Motor priming in neurorehabilitation[J]. J Neurol Phys Ther, 2015, 39(1): 33-42.
doi: 10.1097/NPT.0000000000000065 pmid: 25415551 |
| [6] | SANTOS H, BALEIA I, XAVIER A, et al. Effects of priming therapies on motor dysfunctions and cortical excitability in stroke patients: systematic review[J]. RevSALUS, 2022, 4(3): 467. |
| [7] |
DA SILVA E S M, OCAMOTO G N, SANTOS-MAIA G L D, et al. The effect of priming on outcomes of task-oriented training for the upper extremity in chronic stroke: a systematic review and meta-analysis[J]. Neurorehabil Neural Repair, 2020, 34(6): 479-504.
doi: 10.1177/1545968320912760 pmid: 32452242 |
| [8] |
STOYKOV M E, CORCOS D M, MADHAVAN S. Movement-based priming: clinical applications and neural mechanisms[J]. J Mot Behav, 2017, 49(1): 88-97.
doi: 10.1080/00222895.2016.1250716 pmid: 28277966 |
| [9] |
ZHANG L, JIA G, MA J, et al. Short- and long-term effects of robot-assisted therapy on upper limb motor function and activity of daily living in patients post-stroke: a meta-analysis of randomized controlled trials[J]. J Neuroeng Rehabil, 2022, 19(1): 76.
doi: 10.1186/s12984-022-01058-8 |
| [10] |
LI Y C, LIN K C, CHEN C L, et al. Three ways to improve arm function in the chronic phase after stroke by robotic priming combined with mirror therapy, arm training, and movement-oriented therapy[J]. Arch Phys Med Rehabil, 2023, 104: 1195-1202.
doi: 10.1016/j.apmr.2023.02.015 |
| [11] |
MORONE G, COCCHI I, PAOLUCCI S, et al. Robot-assisted therapy for arm recovery for stroke patients: state of the art and clinical implication[J]. Expert Rev Med Devices, 2020, 17(3): 223-233.
doi: 10.1080/17434440.2020.1733408 pmid: 32107946 |
| [12] |
LAI C H, SUNG W H, CHIANG S L, et al. Bimanual coordination deficits in hands following stroke and their relationship with motor and functional performance[J]. J Neuroeng Rehabil, 2019, 16(1): 101.
doi: 10.1186/s12984-019-0570-4 |
| [13] |
MUDIE M H, MATYAS T A. Upper extremity retraining following stroke: effects of bilateral practice[J]. Neurorehabil Neural Repair, 1996, 10(3): 167-184.
doi: 10.1177/154596839601000304 |
| [14] |
MCCOMBE W S, WHITALL J, JENKINS T, et al. Sequencing bilateral and unilateral task-oriented training versus task-oriented training alone to improve arm function in individuals with chronic stroke[J]. BMC Neurol, 2014, 14: 236.
doi: 10.1186/s12883-014-0236-6 |
| [15] |
HSIEH Y W, LIING R J, LIN K C, et al. Sequencing bilateral robot-assisted arm therapy and constraint-induced therapy improves reach-to-press and trunk kinematics in patients with stroke[J]. J Neuroeng Rehabil, 2016, 13: 31.
doi: 10.1186/s12984-016-0138-5 |
| [16] | 张开兵, 胡江宇, 韩若媚, 等. 基于任务导向的康复机器人训练联合双侧上肢训练对脑卒中患者上肢功能恢复的影响[J]. 中华物理医学与康复杂志, 2024, 46(5): 422-425. |
| [17] | 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国各类主要脑血管病诊断要点2019[J]. 中华神经科杂志, 2019, 52(9): 710-715. |
| Chinese Society of Neurology, Chinese Stroke Society. Diagnostic Criteria of Cerebrovascular Diseases in China (Version 2019)[J]. Chin J Neurol, 2019, 52(9): 710-715. | |
| [18] |
BERNHARDT J, HAYWARD K S, KWAKKEL G, et al. Agreed definitions and a shared vision for new standards in stroke recovery research: the Stroke Recovery and Rehabilitation Roundtable taskforce[J]. Neurorehabil Neural Repair, 2017, 31(9): 793-799.
doi: 10.1177/1545968317732668 pmid: 28934920 |
| [19] |
WOODBURY M L, VELOZO C A, RICHARDS L G, et al. Rasch analysis staging methodology to classify upper extremity movement impairment after stroke[J]. Arch Phys Med Rehabil, 2013, 94(8): 1527-1533.
doi: 10.1016/j.apmr.2013.03.007 |
| [20] |
何爱群, 黎景波, 何茂莉, 等. 作业技能再学习策略对脑卒中偏瘫上肢功能效果的随机对照试验[J]. 中国康复理论与实践, 2024, 30(7): 823-830.
doi: 10.3969/j.issn.1006-9771.2024.07.011 |
| HE A Q, LI J B, HE M L, et al. Effect of occupational skills relearning on hemiplegic arm function after stroke: a randomized controlled trial[J]. Chin J Rehabil Theory Pract, 2024, 30(7): 823-830. | |
| [21] |
GERARDIN E, BONTEMPS D, BABUIN N T, et al. Bimanual motor skill learning with robotics in chronic stroke: comparison between minimally impaired and moderately impaired patients and healthy individuals[J]. J Neuroeng Rehabil, 2022, 19(1): 28.
doi: 10.1186/s12984-022-01009-3 |
| [22] |
RECH K D, SALAZAR A P, MARCHESE R R, et al. Fugl-Meyer Assessment scores are related with kinematic measures in people with chronic hemiparesis after stroke[J]. J Stroke Cerebrovasc Dis, 2020, 29(1): 104463.
doi: 10.1016/j.jstrokecerebrovasdis.2019.104463 |
| [23] | FONG N K, NG B, CHAN D, et al. Development of the Hong Kong version of the Functional Test for the Hemiplegic Upper Extremity (FTHUE-HK)[J]. Hong Kong J Occup Ther, 2004, 41(1): 21-29. |
| [24] | 王赛华, 施加加, 孙莹, 等. 简体版改良Barthel指数在脑卒中恢复期中的信度与效度研究[J]. 中国康复, 2020, 35(4): 179-182. |
| WANG S H, SHI J J, SUN Y, et al. Reliability and validity of the simplified version Modified Barthel Index in convalescence period of stroke[J]. Chin J Rehabil, 2020, 35(4): 179-182. | |
| [25] |
COLAMARINO E, MORONE G, TOPPI J, et al. A scoping review of technology-based approaches for upper limb motor rehabilitation after stroke: Are we really targeting severe impairment?[J]. J Clin Med, 2024, 13(18): 5414.
doi: 10.3390/jcm13185414 |
| [26] |
PATEL J, QIU Q Y, YAROSSI M, et al. Exploring the impact of visual and movement-based priming on a motor intervention in the acute phase post-stroke in persons with severe hemiparesis of the upper extremity[J]. Disabil Rehabil, 2017, 39(15): 1515-1523.
doi: 10.1080/09638288.2016.1226419 |
| [27] |
荣积峰, 丁力, 张雯, 等. 康复机器人结合镜像疗法对脑卒中偏瘫患者上肢功能的效果[J]. 中国康复理论与实践, 2019, 25(6): 709-713.
doi: 10.3969/j.issn.1006-9771.2019.06.016 |
| RONG J F, DING L, ZHANG W, et al. Effects of robot-assisted therapy combined with mirror therapy on upper limbs rehabilitation in patients with hemiplegia after stroke[J]. Chin J Rehabil Theory Pract, 2019, 25(6): 709-713. | |
| [28] |
孙亚, 李岩, 傅建明, 等. 机器人辅助的双侧任务导向性训练对脑卒中患者上肢功能的效果[J]. 中国康复理论与实践, 2023, 29(10): 1195-1200.
doi: 10.3969/j.issn.1006-9771.2023.10.011 |
| SUN Y, LI Y, FU J M, et al. Effect of robot-assisted bilateral task-oriented upper limb training on upper limb function of patients with stroke[J]. Chin J Rehabil Theory Pract, 2023, 29(10): 1195-1200. | |
| [29] | MAZZOLENI S, DURET C, GROSMAIRE A G, et al. Combining upper limb robotic rehabilitation with other therapeutic approaches after stroke: current status, rationale and challenges[J]. Biomed Res Int, 2017, 2017: 8905637. |
| [30] |
AHN S Y, BOK S K, LEE J Y, et al. Benefits of robot-assisted upper-limb rehabilitation from the subacute stage after a stroke of varying severity: a multicenter randomized controlled trial[J]. J Clin Med, 2024, 13: 808.
doi: 10.3390/jcm13030808 |
| [31] |
WU J Y, CHENG H, ZHANG J Q, et al. The modulatory effects of bilateral arm training (BAT) on the brain in stroke patients: a systematic review[J]. Neurol Sci, 2021, 42(2): 501-511.
doi: 10.1007/s10072-020-04854-z pmid: 33180209 |
| [32] |
CHEN S, QIU Y, BASSILE C C, et al. Effectiveness and success factors of bilateral arm training after stroke: a systematic review and meta-analysis[J]. Front Aging Neurosci, 2022, 14: 875794.
doi: 10.3389/fnagi.2022.875794 |
| [33] | 田婧, 何志杰, 杨青, 等. 基于功能性近红外光谱技术的卒中后上肢单侧任务与双侧任务的脑功能成像对比观察[J]. 中国卒中杂志, 2022, 17(4): 360-364. |
| [34] |
LIAO W W, WHITALL J, BARTON J E, et al. Neural motor control differs between bimanual common-goal vs. bimanual dual-goal tasks[J]. Exp Brain Res, 2018, 236(6): 1789-1800.
doi: 10.1007/s00221-018-5261-z |
| [35] | 郑雅丹, 胡昔权, 李奎, 等. 双侧上肢训练影响脑梗死患者脑功能重组的fMRI研究[J]. 中华物理医学与康复杂志, 2017, 39(5): 336-341. |
| ZHENG Y D, HU X Q, LI K, et al. Bilateral arm training and cortical reorganization in cerebral infarction: a functional MRI study[J]. Chin J Phys Med Rehabil, 2017, 39(5): 336-341. | |
| [36] |
CHIN L F, HAYWARD K S, BRAUER S G. Factors influencing paretic upper limb use during first 4 weeks after stroke: a cross-sectional accelerometry study[J]. Am J Phys Med Rehabil, 2021, 100(2): 153-160.
doi: 10.1097/PHM.0000000000001539 |
| [37] |
KIM D H, LEE K D, BULEA T C, et al. Increasing motor cortex activation during grasping via novel robotic mirror hand therapy: a pilot fNIRS study[J]. J Neuroeng Rehabil, 2022, 19(1): 8.
doi: 10.1186/s12984-022-00988-7 pmid: 35073933 |
| [38] |
MATSUDA T, WATANABE S, KURUMA H, et al. A comparison of three bimanual coordinations: an fMRI study[J]. J Phys Ther Sci, 2009, 21: 85-92.
doi: 10.1589/jpts.21.85 |
| [39] |
SUN X L, O'SHEA D J, GOLUB M D, et al. Cortical preparatory activity indexes learned motor memories[J]. Nature, 2022, 602(7896): 274-279.
doi: 10.1038/s41586-021-04329-x |
| [40] |
MAURA R M, RUEDA P S, STEVENS R E, et al. Literature review of stroke assessment for upper-extremity physical function via EEG, EMG, kinematic, and kinetic measurements and their reliability[J]. J Neuroeng Rehabil, 2023, 20(1): 21.
doi: 10.1186/s12984-023-01142-7 pmid: 36793077 |
| [1] | WEI Jingyi, WANG Xiaojing, WANG Ran, WEI Chen, MA Sai, LIU Xihua. Effect of acupuncture synchronized speech training on post-stroke motor aphasia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1000-1008. |
| [2] | WANG Xiaojing, WEI Jingyi, WEI Chen, WANG Ran, MA Sai, LIU Xihua. Effect of synchronous acupuncture and articulation training on spastic dysarthria after stroke [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1009-1016. |
| [3] | ZHOU Xinyue, YE Ruixue, MA Yaqi, XU Ying, CAO Longyao, WANG Yulong. Researches on central post-stroke pain: a bibliometric analysis [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1038-1049. |
| [4] | GAO Yunhan, HOU Shanshan, WANG Xinyu, ZHU Chongtian. Effect of brain-computer interface on upper limb motor dysfunction in stroke patients based on functional near-infrared spectroscopy [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1066-1073. |
| [5] | LOU Yantao, WANG Jiawei, XIAO Xiaofei, LI Yanhui. Comparison of effect of cold therapy at different temperature on upper limb delayed onset muscle soreness in young men [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1074-1082. |
| [6] | GAO Fei, LIU Lixu, HU Xueyan, WU Xiaoli, YANG Lingyu, YANG Yuqi, YE Changqing, DU Xiaoxia. Effect of unilateral or bilateral transcranial direct current stimulation on post-stroke dysphagia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 993-999. |
| [7] | ZHANG Ziang, CHEN Jing, SHEN Mengru, GENG Zongxiao, HAN Xue, ZHAO Xu, XU Lei. Comparison of effect of different types of exercise on gait and balance for stroke patients [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 896-905. |
| [8] | WANG Xiaofeng, HU Mengqiao, WANG Yan, WEI Kun, XU Wenzhu, REN Dan, MA Ye. Effect of exoskeleton robot-assisted gait training on lower limb function after stroke and spinal cord injury: a systematic review [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 914-921. |
| [9] | ZHANG Zihan, GUAN Jinzhi, HUANG Xing, ZHOU Li, ZHANG Yaxuan, ZHANG Mengyuan, CHANG Jingling. Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 947-957. |
| [10] | SUN Wanting, YASEN Ailipinai, GONG Xiang, XIAO Yue, GAN Zhaodan, LIU Mingjie, ZENG Lanting, MA Shuyue, LU Jun, XU Guangxu. Effect of high-frequency repetitive transcranial magnetic stimulation on upper limb function of stroke patients based on motor sequence learning [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 812-821. |
| [11] | SHAN Lei, LIU Ying, ZHANG Xin, CHI Qianqian, ZHU Xiaomin. Effect of accelerated intermittent theta burst stimulation on post-stroke depression [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 822-829. |
| [12] | LIU Lanqun, LI Yanli, LIANG Jiaqi, CHEN Shuang, LIU Huilin. Effect of scalp acupuncture combined with computer-assisted training on memory impairment after stroke [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 862-868. |
| [13] | LIU Xuan, GAO Ling, CHU Fengming, CHEN Jie, ZHANG Ming. Effect of brain-computer interface combined with upper limb rehabilitation robot on upper limb function of stroke patients [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(6): 703-710. |
| [14] | ZHOU Tiantian, ZHANG Tong, ZHANG Qi, LIANG Yanhua, ZHANG Yanqing, YUE Qing, LI Sijia. Effect of Lokomat robotic-assisted gait training on lower limb motor function in children with hemiplegia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(6): 711-720. |
| [15] | FU Guojun, YU Xiufang, LÜ Xin, JI Lu, LIU Huaqing. Effect of composite electromagnetic stimulation combined with chin tuck against resistance on post-stroke patients with dysphagia [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(6): 721-728. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
|
||