Abstract: Objective To explore the effects of cognitive behavioral therapy and citalopram on regional cerebral blood flow(rCBF)in the patients with depression disorder.Methods 38 patients with depression disorder were divided into the cognitive behavioral therapy group(n=18),and citalopram group(n=20).The rCBF changes and scores of Hanmilton Depression Scale(HAMD)of all patients in two groups were evaluated with ⁹⁹Tc^m-ECD single photon emission computed tomography(SPECT)and HAMD before and after treatment.Results After treatment,the symptoms of all patients in two groups improved,but the cases of the citalopram group got a rapid improvement compared with those of the cognitive behavioral therapy group.Both of two methods could increase blood flow in right basal ganglion;while,the blood flow also increased in right limbic system in the cognitive behavioral therapy group,and in right temporol lobule in the citalopram group.Conclusion Both cognitive behavioral therapy and citalopram are effect on symptoms of depression disorder,but affect blood flow in different parts.

Key words: depression disorder, cognitive behavioral therapy, citalopram, single photon emission computed tomography(SPECT), Hanmilton Depression Scale