Abstract: Objective To evaluate the effectiveness and safety of Botulinum toxin-A(BTX-A)injection into detrusor to treat neurogenic detrusor overactivity in patients with spinal cord injury(SCI).MethodsA total of 78 patients with SCI were treated with transurethral injection of BTX-A(300 IU dissolved in 15 ml of saline)into 30 different points of detrusor with 15 ml in every patients.Urodynamic parameters and voiding diary were assessed at baseline and 3 weeks and 3 months after the injections.Adverse events were recorded after the injection if present.ResultsAfter the first injection,78 patients showed that the mean frequencies of incontinence decreased from 13.5 to 2.7 times per day,the mean volume of intermittent catheterization(IC)increased from 131 ml to 389 ml per time,the mean volume of incontinence decreased from 1 690 ml to 281 ml per day,the mean getting effect time was 7.6 days.10 patients received second injection at 8.9 months after first injection,the results showed that the mean frequencies of incontinence decreased from 9.7 to 3.7 times per day,the mean IC volume increased from 108 ml to 387 ml.6 patients received third injection at 5.8 months after second injection,the results showed that the mean frequencies of incontinence decreased from 9.2 to 3.9 times per day,the mean IC volume increased from 116 ml to 364 ml.No side effects were observed during the follow-up.ConclusionBTX-A injection into detrusor to treat neurogenic detrusor overactivity in patients with SCI seems to be an effective,safe and miniinvasive solution.

Key words: botulinum toxin-A(BTX-A), detrusor, neurogenic bladder, spinal cord injury