Abstract: The need to find an alternative to the use of bowel for urinary reconstruction has renewed research interests involving bladder regeneration. Small intestinal submucosa (SIS) is an acellular, nonimmunogenic, biodegradable, xenogeneic, collagen-based material that is derived from the submucosa layer of porcine small intestine. SIS has demonstrated regenerative capacities in multiple organ systems, including the aorta, vena cava, ligaments, tendons, abdominal wall, and skin. This article reviewed the history of the development of the bladder regeneration and the studies involving the use of SIS for bladder augmentation.

Key words: small intestinal submucosa, bladder regeneration, cystoplasty, review