Abstract: Objective To investigate the effect of cognitive behavioral multi-level intervention on post-stroke depression. Methods 160 patients with post-stroke depression in our hospital from February 2013 to February 2015 were divided into control group (n=80) and observation group (n=80). Both groups received conventional medical treatment and nursing care. The observation group received cognitive behavioral multi-level intervention nursing care, including personal psychology, behaviour and joint relationship. Self-rating Depression Scale (SDS) was assessed, and the serum level of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α) were mesured before and after treatment. Results After treatment, the score of SDS was lower (t=2.705, P<0.05), and the levels of IL-1β (t=8.182), IL-6 (t=2.883), TNF-α (t=2.604) were lower in the observation group than in the control group (P<0.05). The incidence of depression was also lower in the observation group than in the control group ( χ 2=6.144, P<0.05) after 6 months follow-up. Conclusion Cognitive behavioral multi-level intervention could effectively prevent post-stroke depression.

Key words: stroke, depression, cognitive behavioral therapy, multi-level intervention, nursing