静息态脑电图在脑卒中患者上肢运动功能评估中的应用

doi:10.3969/j.issn.1006-9771.2025.04.010

Abstract

Abstract:

Objective To investigate the features of resting-state electroencephalography (EEG) in stroke patients with limited upper limb movement, and assess its potential utility in evaluating upper limb motor function.
Methods From March to August, 2024, a total of 71 stroke patients with limited upper limb movement were enrolled as stroke group at the Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine; while 63 healthy participants matched for age and sex were recruited as control group. They were tested with 19-channel resting-state EEG (rsEEG), calculating of the pairwise derived brain symmetry index (pdBSI) and Delta/Alpha ratio (DAR). The motor function was assessed with Fugl-Meyer Assessment-Upper Extremities (FMA-UE), the upper limb recovery was evaluated with Brunnstrom Stages and the activities of daily living was assessed with modified Barthel index (MBI) in stroke patients,
Results Compared with the control group, the pdBSI of Global lead, Frontal region, Central region and Posterior region across Delta, Alpha and Beta1 frequency bands were significantly higher in the stroke group than in the control group (|Z| > 2.289, P < 0.05); as well as the pdBSI of Global lead, Central region and Posterior region across Theta bands (|Z| > 3.016, P < 0.01), the pdBSI of Global lead, Frontal region, Central region and Posterior region across Beta2 bands (|Z| > 3.222, P < 0.01), DAR of Global lead, Frontal region, Central region and Posterior region (|Z| > 6.565, P < 0.001). In the stroke group, the pdBSI of Global lead (r = -0.280, P = 0.018) and Central region (r = -0.304, P = 0.010) across the Delta band were significantly negatively correlated with FMA-UE, as well as the pdBSI of Global leads (r = -0.289, P = 0.014), Central region (r = -0.244, P = 0.040) and Posterior region (r = -0.356, P = 0.002) across the Beta1 band, and the DAR of Global lead (r = -0.431, P < 0.001), Frontal region (r = -0.429, P < 0.001), Central region (r = -0.491, P < 0.001) and Posterior region(r = -0.482, P < 0.001).
Conclusion Asymmetry in spectral power between hemispheres in the Delta (0.5 to 4 Hz) and Beta (13 to 20 Hz) bands is found in stroke patients, especially in the central region, which correlates with upper limb function limitations. pdBSI Delta, pdBSI Beta1 and DAR are potential neuroelectrophysiological markers for assessing upper limb motor function in stroke patients.

Key words: stroke, electroencephalogram, upper extremety, motor function

CLC Number:

R743

LI Xinlei, WEI Wei, SONG Jian, ZHAO Yuqing, KONG Weicheng, CAI Jiayu, SHI Haoran, XUE Xiehua. Application of resting-state electroencephalography in assessment of upper limb motor function of stroke patients[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(4): 448-457.

Figures/Tables 8

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References 33

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组别	n	性别(男/女)/n	年龄/岁
对照组	63	41/22	64.00(55.00, 69.00)
卒中组	71	53/18	61.00(50.00, 70.00)
χ²/Z值		1.460	-0.446
P值		0.227	0.656

rsEEG指标	导联区域	对照组	卒中组	Z值	P值
pdBSI Delta	全局导联	0.04(0.00,0.10)	0.11(0.10,0.20)	-4.798	< 0.001
	额叶区域	0.06(0.00,0.10)	0.15(0.10,0.30)	-5.605	< 0.001
	中央区域	0.06(0.00,0.10)	0.12(0.10,0.30)	-4.270	< 0.001
	后部区域	0.06(0.00,0.10)	0.12(0.10,0.30)	-4.062	< 0.001
pdBSI Theta	全局导联	0.06(0.00,0.10)	0.09(0.00,0.20)	-3.112	0.002
	额叶区域	0.08(0.00,0.10)	0.10(0.00,0.20)	-1.047	0.295
	中央区域	0.06(0.00,0.10)	0.12(0.10,0.20)	-3.016	0.003
	后部区域	0.07(0.00,0.10)	0.12(0.10,0.20)	-3.221	0.001
pdBSI Alpha	全局导联	0.04(0.00,0.10)	0.080(0.00,0.20)	-4.032	< 0.001
	额叶区域	0.06(0.00,0.10)	0.07(0.00,0.20)	-2.289	0.022
	中央区域	0.05(0.00,0.10)	0.110(0.10,0.20)	-4.045	< 0.001
	后部区域	0.08(0.00,0.10)	0.12(0.10,0.20)	-2.294	0.022
pdBSI Beta1	全局导联	0.05(0.00,0.10)	0.09(0.10,0.20)	-4.270	< 0.001
	额叶区域	0.06(0.00,0.10)	0.11(0.10,0.20)	-3.549	< 0.001
	中央区域	0.09(0.00,0.20)	0.12(0.10,0.20)	-2.430	0.015
	后部区域	0.08(0.00,0.10)	0.12(0.10,0.20)	-3.359	0.001
pdBSI Beta2	全局导联	0.06(0.0,0.1)	0.130(0.1,0.2)	-3.957	< 0.001
	额叶区域	0.08(0.0,0.1)	0.150(0.1,0.2)	-3.222	0.001
	中央区域	0.15(0.1,0.2)	0.200(0.1,0.3)	-1.851	0.064
	后部区域	0.06(0.0,0.1)	0.140(0.1,0.2)	-3.387	0.001
DAR	全局导联	0.79(0.5,1.3)	2.76(1.30,4.80)	-7.012	< 0.001
	额叶区域	1.06(0.6,2.00)	3.72(1.70,7.00)	-6.825	< 0.001
	中央区域	0.86(0.60,1.30)	2.82(1.30,4.80)	-6.756	< 0.001
	后部区域	0.51(0.30,0.80)	1.82(0.80,3.60)	-6.565	< 0.001

rsEEG指标	AUC	SE	敏感性	特异性	95% CI	P值
pdBSI Delta(Global)	0.740	0.042	0.493	0.968	0.657~0.823	< 0.001
pdBSI Delta(Central)	0.714	0.045	0.606	0.794	0.626~0.801	< 0.001
pdBSI Beta1(Global)	0.714	0.044	0.704	0.651	0.627~0.800	< 0.001
pdBSI Beta1(Central)	0.622	0.048	0.451	0.730	0.527~0.716	0.015
pdBSI Beta1(Posterior)	0.668	0.047	0.620	0.667	0.577~0.759	0.001
DAR(Global)	0.852	0.033	0.662	1.000	0.787~0.917	< 0.001
DAR(Frontal)	0.842	0.034	0.662	0.952	0.776~0.909	< 0.001
DAR(Central)	0.839	0.035	0.690	0.921	0.770~0.907	< 0.001
DAR(Psterior)	0.829	0.037	0.676	0.921	0.758~0.901	< 0.001

Application of resting-state electroencephalography in assessment of upper limb motor function of stroke patients

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