Abstract: Drug addiction is a chronic and relapsing brain disease, which causes damage to the health of addicts seriously, and causes huge social problems. Relapse is one of the major characteristics of drug addiction, and is the main problem to be solved. In the past several decades, the mechanisms, high relapse rates, abstinence of addiction were studied. The Results of these research findings are summarized in this review to provide a better overview of the mechanisms and treatments of addition in order to provide ideas for further research.

Key words: drug addiction, cingulotomy, nucleus accumbens, deep brain stimulation