Abstract: Objective To investigate the expressions of Transforming Growth Factorβ₂ (TGF-β₂) and Smad3 in human gliomas associated with pathologic grading. Methods The expressions of TGFβ₂ and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens. The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank. Results The expression of TGFβ₂ and Smad3 correlated with the pathological grading (r=0.545, r=0.570, P<0.01). Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group (P<0.05). Conclusion Both TGF-β₂ and Smad3 correlate well with the occurrence and differentiation of human gliomas,which help for the diagnosis, treatment and prognosis judgment．

Key words: glioma, transforming growth factor β₂, Smad3, immunhistochemistry