《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2008, Vol. 14 ›› Issue (02): 147-149.
• 基础研究 • Previous Articles Next Articles
WU Xiao-yan, CHEN Wei, YU Mao-hua
Received:
Published:
Online:
Abstract: Objective To investigate the effect of astragalus polysaccharide(APS)on expression of interleukin-4(IL-4)and interferon-γ(IFN-γ)in non-obese diabetic(NOD)mice.Methods 20 NOD mice were randomly divided into the APS group and control group with 10 animals in each group.The mice of the APS group took APS 2 g/kg/d orally for two months.The animals of the control group took same quantity saline.The incidence rate of type 1 diabetes mellitus of two groups was calculated,and pancreatic histopathology was observed with microscope,and expression of IL-4 and IFN-γ were examined with RT-PCR for both APS group and control group.Results The incidence rate of type 1 diabetes mellitus of the APS group was lower than the control group,and histopathology of islets were more protected,expression of IFN-γ was lower and expression of IL-4 was higher in the APS group.Conclusion APS may correct the imbalance of cytokines.
Key words: astragalus polysaccharide, type 1 diabetes mellitus, cytokines
WU Xiao-yan;CHEN Wei;YU Mao-hua. Effect of Astragalus Polysaccharides on Expression of IL-4 and IFN-γ in Non-obese Diabetic Mice [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2008, 14(02): 147-149.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: https://www.cjrtponline.com/EN/
https://www.cjrtponline.com/EN/Y2008/V14/I02/147