Abstract: Post-menopause hypertension in female is the appearance of elevation of blood pressure in one year after menopause.It will always bring obesity,blood lipid abnormality,disorders of carbohydrate metabolism,elevation of insulin's leave,elevation of sympathetic nerve's irritability,and so on by the hormone leave and other reason,which has caused wide public concern as one of the reason of coronary heart disease(CHD).The possible pathogenesis of female hypertension is complicated and many factors.These disorders may include decrease of estrogen,overfull pituitrin,putting on weight,composite factors and others unknown neurohumoral factors.During the treatment of high blood pressure,considering the diversity of post-menopause female,it need take concrete illness into account to choose reducing the pressure drug.There are many experiments to approve applied hormone replacement therapy(CRT),but it is still incertitude on post-menopause hypertensive female sufferer.At the same time,hypertension is not the contraindication in application of HRT.It need more advanced stochastic clinical experimentation to prove whether CHD female could benefit from HRT application.

Key words: post-menopause hypertension, estrin, hormone replacement therapy, review