Abstract: Motor function is the main function of human being takes place the social activities in the world. Unfortunately, regardless of either CNS or PNS injury, the outcome usually is paralysis. Up to date there is still no drug may restore the function of paralyzed limbs rapidly, completely and satisfactorily. However, the scientist have used drugs to enhance motor function recovery after brain injury and got some effects since the mid of past century, e.g. the amphetamine. The function of amphetamine, notwithstanding was denied by Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Adult Stroke Rehabilitation Care in 2005, however, there were other reports concerning with same purpose study, that may facilitate the recovery of motor function, e.g. Fluoxetine, Selegiline, L-dopa and so on. In the meantime, there also found some drugs with opposite effect and slowing the functional recovery, e.g., Haloperidol, Prazosin, Phenytoin and so forth.

Key words: brain injury, motor function impaired, drug rehabilitation