Abstract: Objective To observe the effects of cornel iridoid glycoside (CIG) on nervous function and neuronal survival in focal cerebral ischemic rat model.MethodsThe animal model was induced by occlusion of middle cerebral artery with suture embolus. Nervous function defect and survival number of neuron were detected with nervous function score and Nissl's staining respectively.ResultsCompared with Sham operation group, nervous function score increased and nervous survival number decreased obviously in model rats. Compared with model group, CIG decreased nervous function score and increased survival neurons significantly. ConclusionCIG may have theraputic effect on cerebral infarct through improving nervous function and increasing survival neurons.

Key words: cornel iridoid glycoside, cerebral infarct, nervous function score, neuronal survival