Abstract: ObjectiveTo summarize the clinical features of reported 425 domestic cases of POEMS syndrome, and its diagnosis and treatment.MethodsClinical characteristics of 425 POEMS cases were summarized with meta analysis.ResultsPOEMS syndrome usually occurred in middle-age males, and its onset age ranged from 11 to 74 years, averaged 43 years. Clinical display was characterized by a combination of polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes. It usually occurred with osteomyeloma. Most patients died of serious infections, respiratory insufficiency or heart failure. The treatment with glycocorticosteroid had led to short-time improvement.ConclusionThe patients in our country more present as peripheralneuropathy, skin change and edema, whereas hepatomegaly, splenomegaly, erectile dysfunction, breast enlargement of males, amenorrheal, pleural effusion and ascites are next.

Key words: POEMS syndrome, peripheralneuropathy, myeloma