《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2006, Vol. 12 ›› Issue (08): 685-684.
• 基础研究 • Previous Articles Next Articles
GAO Yu-ling, MAJing,CHEN Yu-juan, et al
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Abstract: ObjectiveTo investigate the effect of hyperlipidemia on monophasic action potential and calcium current of heart in rabbits.Methods24 rabbits were divided into the high cholesterol group (n=12) and control group (n=12) and fed with high cholesterol forage and standard forage respectively for 10 weeks. Electrocardiograph, ventricular fibrillation threshold and the level of serum lipid were examined. Whole-cell patch clamp technique was used to record I_ Ca-L.ResultsIn high cholesterol group, the serum cholesterol level was higher than the control group ( P<0.01), ventricular fibrillation threshold (10.2±1.7 V) lower than that of the control group (13.9±1.3 V)( P<0.05), MAPD90 displayed more significant rate-dependent prolongation. At cycle lengths of 1500 ms, MAPD90 was 358±18 ms in the high cholesterol group, while it was 277±20 ms in the control group. The densities of ICa-L were larger in the high cholesterol group (14.7±0.8 pA/pF) than that in the control group (10.9±1.1 pA/pF)( P<0.01).ConclusionHypercholesterolemia can produce cardiac electrical remodeling, including increased ICa-L, prolonged repolarization and decreased ventricular fibrillation thresholds.
Key words: hypercholesterolemia, rabbit, ventricular fibrillation threshold, monophasic action potential, calcium current
GAO Yu-ling;MAJing;CHEN Yu-juan;et al. Characteristics of Monophasic Action Potential and Calcium Current of Heart in Rabbit with Hyperlipidemia [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2006, 12(08): 685-684.
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