Abstract: ObjectiveTo explore the effects of early rehabilitation on premature infant with brain damage. Methods101 premature infants with brain damage in were divided into experimental group （n=45） and control group （n=56）. The experimental group received medicine and early rehabilitation. The control group received medicine only. Developmental evaluation were performed in 3, 6, 9, and 12 months old. ResultsThere were no significant differences of the Neonatal Behavioral Neurological Assessment (NBNA) scores between these two groups （P＞0.05）. Except infants of 3 months old, the developmental quotient (DQ) and mental index (MI) of 9, 12 months old infants of the experimental group were higher than that of the control group （P＜0.01）. The sequelae of the experimental group were less than that of the control group （P＜0.05）. ConclusionEarly rehabilitation can promote development of premature infant with brain damage and reduce the sequelae.

Key words: early rehabilitation, premature, brain damage