Abstract: Objective To explore the relationship between first-episode schizophrenia and metabolic syndrome (MS). Methods 231 first-episode schizophrenia patients (schizophrenia group) and 63 healthy controls (healthy group) were selected to detect the height, weight, waistline, fasting plasma glucose (FPG), blood lipid and blood pressure. International Diabetes Federation (IDF) MS Diagnostic Criterion (2005) was used to diagnose MS. Results The FPG and Total Cholesterol (TC) of the schizophrenia group were significantly higher than the control group (P<0.001). The MS detection rate in the schizophrenia group was higher than in the control group (P=0.021). Conclusion First-episode schizophrenia patients could have glucose-lipid metabolism disorder during the early stage.

Key words: schizophrenia, first-episode, metabolic syndrome, case-control study