《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2012, Vol. 18 ›› Issue (5): 420-422.

• 论文 • Previous Articles     Next Articles

Effect of Body Weight Support Treadmill Training and Electroacupuncture on Expression of Brain-derived Neurotrophic Factor inSpinal Cord Injuried Rats

LIU Shuai, XING Yan-li, MENG Wei.   

  1. Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang,China
  • Received:2011-11-08 Revised:2011-12-16 Published:2012-05-25 Online:2012-05-25

Abstract: Objective To investigate the mechanism of body weight support treadmill training (BWSTT) and electroacupuncture (EA)for spinal cord injury. Methods 56 adult SD rats were divided into control group (n=16), EA group (n=16), BWSTT-EA group (n=16) andblank group (n=8). They were treated 3 d after operation, and assessed with Basso-Beattie-Bresnahan (BBB) scale and the brain-derived neurotrophicfactor (BDNF) was measured in injured tissue with real time immunohistochemisty assay 1 d, 7 d, 14 d, 21 d after treatment. ResultsThe score of BBB was significantly higher in the BWSTT- EA group than in control group and EA group 1 d, 7 d, 14 d, 21 d after treatment(P<0.05), as well as the expression of BDNF (P<0.05). Conclusion BWSTT and EA can promote the recovery of spinal cord injury,which may associate with the expression of BDNF in injured tissue.

Key words: spinal cord injury, electroacupuncture, body weight support treadmill training, brain-derived neurotrophic factor, rats