《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2021, Vol. 27 ›› Issue (12): 1443-1449.doi: 10.3969/j.issn.1006-9771.2021.12.010
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YANG Zhao-yu1,LI Pei-jun1,LI Jian1,LIU Xiao-dan2,WU Wei-bing1()
Received:
2021-07-26
Revised:
2021-11-09
Published:
2021-12-25
Online:
2021-12-29
Contact:
WU Wei-bing
E-mail:wwb75@126.com
Supported by:
CLC Number:
YANG Zhao-yu,LI Pei-jun,LI Jian,LIU Xiao-dan,WU Wei-bing. Effect of Exercise on Chronic Obstructive Pulmonary Disease Systemic Inflammation and Skeletal Muscle Dysfunction: A Systematic Review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1443-1449.
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研究文献 | n (T/C) | 运动方式 | 运动方案 | 系统性炎症结局指标 | 骨骼肌功能及结构结局指标 |
---|---|---|---|---|---|
孙丽等[ (2016) | 26/25 | 有氧运动 | 每次60 min,每天1次,每周4~5 d,共12周 | CRP、TNF-ɑ下降;IL-6、Fbg无显著性差异 | 6分钟步行试验增加 |
Toledo-Arruda等[ | 24/24 | 有氧运动 | 每次30 min,每天2次,每周5 d,共12周 | TNF-α下降;IL-10升高 | 最大运动速度、运动耐力增加 |
Menon等[ | 17/10 | 抗阻运动 | 每组30次,每天5组,每周3 d,共8周 | 中性粒细胞、CD163+减少 | Ⅱ型肌纤维横截面积、肌卫星细胞增加 |
Silva等[ (2018) | 24/11 | 抗阻运动 | 每次60 min,每周3次,共12周 | IL-6、TNF-α、IL-15下降;IL-10无显著性差异 | 屈肘、伸膝肌肌力增加 |
Troosters等[ | 20(前后对照) | 抗阻运动 | 每次3组,每天8次,共7 d | CRP无显著性差异 | 股四头肌肌力、6分钟步行试验距离增加;Myogenin mRNA降低;IGF-1、MURF-1、MGF、MyoD、Atrogin-1蛋白表达无显著性差异 |
Krüger等[ | 10/10 | 高强度间歇运动 | 每次30 min,每周5次,共8周 | IL-1β、TNF-α下降 | 肌纤维横截面积、Ⅰ型纤维相对比例、IGF-1蛋白表达增加;Atrogin-1、MURF-1 mRNA降低 |
Vogiatzis等[ | 15(前后对照) | 高强度间歇运动 | 每天45 min,每周3 d,共10周 | TNF-ɑ、IL-6无显著性差异 | 肌纤维横截面积,MyoD、IGF-1、MGF mRNA,MyoD、IGF-1蛋白表达增加 |
Vogiatzis等[ | 正常体质量组(n = 19);低体质量组(n = 10) | 高强度间歇运动 | 每天45 min,每周3 d,共10周 | TNF-ɑ、IL-6无显著性差异 | 正常体质量组: Atrogin-1、MURF-1蛋白表达,Ⅱb型纤维占比降低; MyoD、IGF-1蛋白表达增加。 低体质量组: Atrogin-1、MURF-1、MyoD、IGF-1蛋白表达增加; Ⅱb型纤维占比降低 |
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