运动对慢性阻塞性肺疾病系统性炎症和骨骼肌功能障碍干预效果的系统综述

doi:10.3969/j.issn.1006-9771.2021.12.010

Abstract

Abstract:

Objective To systematically review the effects of exercise on systemic inflammation of chronic obstructive pulmonary disease (COPD) and skeletal muscle dysfunction.Methods The literature about the effect of exercise on COPD systemic inflammation and skeletal muscle dysfunction were retrieved from PubMed, Web of Science, CNKI, VIP and Wanfang data, until June, 2021, supplemented by reference review and manual retrieval.Results A total of 192 literatures were retrieved and eight were included, involving 245 subjects. The comprehensive results showed that exercise could decrease the level of pro-inflammatory factors and increase the level of anti-inflammatory factors. Exercise can improve the motor ability and skeletal muscle structure of patients with COPD. Exercise can improve systemic inflammation of COPD, which is related to the mode, intensity and duration of exercise. Exercise may affect ubiquitin-protease, insulin-like growth factors -1/phosphatidylinositol 3 kinase/Akt and other pathways by regulating the inflammatory response, and improve skeletal muscle dysfunction.Conclusion Exercise has certain effect on reducing systemic inflammation and improving skeletal muscle dysfunction.

Key words: chronic obstructive pulmonary disease, skeletal muscle dysfunction, systemic inflammation, exercise, systematic review

CLC Number:

R562.2

YANG Zhao-yu,LI Pei-jun,LI Jian,LIU Xiao-dan,WU Wei-bing. Effect of Exercise on Chronic Obstructive Pulmonary Disease Systemic Inflammation and Skeletal Muscle Dysfunction: A Systematic Review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1443-1449.

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References 45

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研究文献	n (T/C)	运动方式	运动方案	系统性炎症结局指标	骨骼肌功能及结构结局指标
孙丽等^[35] (2016)	26/25	有氧运动	每次60 min,每天1次,每周4~5 d,共12周	CRP、TNF-ɑ下降;IL-6、Fbg无显著性差异	6分钟步行试验增加
Toledo-Arruda等^[30](2017)	24/24	有氧运动	每次30 min,每天2次,每周5 d,共12周	TNF-α下降;IL-10升高	最大运动速度、运动耐力增加
Menon等^[36] (2012)	17/10	抗阻运动	每组30次,每天5组,每周3 d,共8周	中性粒细胞、CD₁₆₃⁺减少	Ⅱ型肌纤维横截面积、肌卫星细胞增加
Silva等^[31] (2018)	24/11	抗阻运动	每次60 min,每周3次,共12周	IL-6、TNF-α、IL-15下降;IL-10无显著性差异	屈肘、伸膝肌肌力增加
Troosters等^[37](2010)	20(前后对照)	抗阻运动	每次3组,每天8次,共7 d	CRP无显著性差异	股四头肌肌力、6分钟步行试验距离增加;Myogenin mRNA降低;IGF-1、MURF-1、MGF、MyoD、Atrogin-1蛋白表达无显著性差异
Krüger等^[28] (2018)	10/10	高强度间歇运动	每次30 min,每周5次,共8周	IL-1β、TNF-α下降	肌纤维横截面积、Ⅰ型纤维相对比例、IGF-1蛋白表达增加;Atrogin-1、MURF-1 mRNA降低
Vogiatzis等^[20] (2007)	15(前后对照)	高强度间歇运动	每天45 min,每周3 d,共10周	TNF-ɑ、IL-6无显著性差异	肌纤维横截面积,MyoD、IGF-1、MGF mRNA,MyoD、IGF-1蛋白表达增加
Vogiatzis等^[38] (2010)	正常体质量组(n = 19);低体质量组(n = 10)	高强度间歇运动	每天45 min,每周3 d,共10周	TNF-ɑ、IL-6无显著性差异	正常体质量组： Atrogin-1、MURF-1蛋白表达,Ⅱb型纤维占比降低; MyoD、IGF-1蛋白表达增加。低体质量组： Atrogin-1、MURF-1、MyoD、IGF-1蛋白表达增加; Ⅱb型纤维占比降低

Effect of Exercise on Chronic Obstructive Pulmonary Disease Systemic Inflammation and Skeletal Muscle Dysfunction: A Systematic Review

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