头穴丛刺联合太极拳对卒中后抑郁患者脑功能连接及网络拓扑的影响

doi:10.3969/j.issn.1006-9771.2026.06.001

Abstract

Abstract:

Objective To explore the effect of cluster scalp acupuncture combined with Taijiquan training on depressive symptom, motor function, activities of daily living, serum markers, as well as brain functional connectivity (FC) and network topological properties in patients with post-stroke depression (PSD).
Methods A total of 40 PSD patients in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from September, 2022 to September, 2023 were enrolled and randomly divided into control group (n=20) and experimental group (n=20). The control group received cluster scalp acupuncture alone, while the experimental group underwent Taijiquan training in addition, for four weeks. They were assessed with Hamilton Depression Scale-17 (HAMD-17), Fugl-Meyer Assessment (FMA) and Barthel Index (BI) before and after treatment, while the serum levels of dopamine (DA), 5-hydroxytryptamine (5-HT), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected with enzyme-linked immunosorbent assay. Resting-state functional magnetic resonance imaging (rs-fMRI) was applied to assess brain FC, as well as the global efficiency (Eg) and small-world property (σ) of brain networks.
Results The scores of HAMD-17, FMA and BI improved in both groups (t>2.922,P<0.01) after treatment, and improved more in the experimental group than in the control group (t>2.517,P<0.05). The serum levels of DA and 5-HT increased in both groups (t>2.637,P<0.05), and increased more in the experimental group (t>2.192,P<0.05). The serum levels of IL-6 and TNF-α decreased in the experimental group after treatment (t>4.059,P<0.001), and they were less than those in the control group (t>2.154,P<0.05). FC between left middle frontal gyrus and right anterior cingulate gyrus, as well as between left hippocampus and right precuneus were higher in the experimental group than in the control group after treatment (t>3.867,P<0.001), while Eg and σ increased in both groups (t>2.828,P<0.05), and they were higher in the experimental group (t>2.675,P<0.05).
Conclusion Combination of Taijiquan training is more effective on depressive symptoms, motor function and activities of daily living in PSD patients, which may be related to up-regulation of serum DA and 5-HT, reduction of inflammatory factors, enhancement of prefrontal-limbic system functional connectivity and optimization of brain network topological properties.

Key words: post-stroke depression, cluster scalp acupuncture, Taijiquan, functional connectivity, brain network topology

CLC Number:

R743.3

GUAN Yujie, LIU Keyan, YANG Keqin, LIANG Yulin, ZHANG Jinpeng, ZHAO Bin. Effect of cluster scalp acupuncture combined with Taijiquan on brain functional connectivity and network topology for patients with post-stroke depression[J]. Chinese Journal of Rehabilitation Theory and Practice, 2026, 32(6): 621-630.

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References 43

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组别	n	性别 (男/女)/n	年龄/岁	病程/d	疾病性质 (出血/梗死)/n	受教育年限/年	高血压/n	糖尿病/n	MMSE
对照组	20	7/13	66.51±8.50	35.50±11.50	4/16	9.50±2.65	19	18	28.20±1.01
试验组	20	9/11	64.50±8.50	38.50±13.90	5/15	8.50±3.59	17	16	28.75±0.85
χ²/t值		0.417	0.747	0.744	0.156	1.002	0.417	0.784	1.868
P值		0.519	0.460	0.462	0.693	0.323	0.292	0.376	0.070

组别	n	测试	$\stackrel{-}{\mathit{x}}\pm \mathit{s}$	t值	P值
对照组	20	前测	20.15±6.50	2.922	0.009
		后测	15.50±5.50
试验组	20	前测	20.90±6.73	5.047	<0.001
		后测	11.50±4.50
治疗前两组均值差			-0.75±2.10	0.357	0.723
治疗后两组均值差			4.00±1.59	2.517	0.016

组别	n	测试	$\stackrel{-}{\mathit{x}}\pm \mathit{s}$	t值	P值
对照组	20	前测	35.50±5.24	8.366	<0.001
		后测	46.27±6.50
试验组	20	前测	35.68±5.83	9.332	<0.001
		后测	52.50±8.50
治疗前两组均值差			-0.18±1.75	0.103	0.919
治疗后两组均值差			-6.23±2.39	2.604	0.013

组别	n	测试	$\stackrel{-}{\mathit{x}}\pm \mathit{s}$	t值	P值
对照组	20	前测	36.51±7.42	3.339	0.003
		后测	43.51±6.49
试验组	20	前测	38.51±6.50	4.741	<0.001
		后测	49.50±7.49
治疗前两组均值差			-2.00±2.20	0.907	0.370
治疗后两组均值差			-5.99±2.22	2.703	0.010

变量	组别	n	测试	$\stackrel{-}{\mathit{x}}\pm \mathit{s}$	t值	P值
DA/(ng·mL^-1)	对照组	20	前测	115.50±14.50	2.890	0.009
			后测	129.51±14.50
	试验组	20	前测	112.50±13.50	7.060	<0.001
			后测	142.50±15.50
	治疗前两组均值差			3.00±4.43	0.676	0.503
	治疗后两组均值差			-12.99±4.75	2.738	0.009
5-HT/(ng·mL^-1)	对照组	20	前测	58.51±6.51	2.637	0.016
			后测	64.95±7.48
	试验组	20	前测	59.50±6.49	5.146	<0.001
			后测	70.50±8.49
	治疗前两组均值差			-1.00±2.06	0.486	0.629
	治疗后两组均值差			-5.55±2.53	2.192	0.035
IL-6/(pg·mL^-1)	对照组	20	前测	19.50±5.50	1.843	0.081
			后测	15.92±5.50
	试验组	20	前测	20.50±6.50	4.245	<0.001
			后测	12.50±4.50
	治疗前两组均值差			-1.00±1.90	0.526	0.602
	治疗后两组均值差			3.42±1.59	2.154	0.038
TNF-α/(pg·mL^-1)	对照组	20	前测	25.50±6.09	1.914	0.071
			后测	21.50±5.50
	试验组	20	前测	25.50±6.50	4.059	<0.001
			后测	17.73±4.77
	治疗前两组均值差			0.00±1.99	0.001	1.000
	治疗后两组均值差			3.76±1.63	2.313	0.026

Effect of cluster scalp acupuncture combined with Taijiquan on brain functional connectivity and network topology for patients with post-stroke depression

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变量	组别	n	测试	$\stackrel{-}{\mathit{x}}\pm \mathit{s}$	t值	P值
Eg	对照组	20	前测	0.173±0.008	4.778	0.002
			后测	0.185±0.006
	试验组	20	前测	0.177±0.006	6.511	<0.001
			后测	0.192±0.003
	治疗前两组均值差			-0.004±0.004	1.152	0.269
	治疗后两组均值差			-0.007±0.002	2.944	0.011
σ	对照组	20	前测	0.520±0.079	2.828	0.025
			后测	0.631±0.062
	试验组	20	前测	0.582±0.045	6.804	<0.001
			后测	0.723±0.074
	治疗前两组均值差			-0.062±0.032	1.948	0.072
	治疗后两组均值差			-0.092±0.034	2.675	0.018

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