Stroke patients often suffer from fatigue after exercise, which influences the limb function and the quality of life. Also, it may be related to the increase of mortality. Fatigue Severity Scale, Fatigue Assessment Scale and other scales are suitable for the subjective assessment. The critical flicker frequency and the reaction time are important physiological indexes. And blood lactic acid, creatine kinase, serum tryptophan and glucose are significant biochemical indexes. The effective treatment for the exercise-induced fatigue is still in the exploratory stage, it mainly includes drug therapy, physical therapy, nutrition diet, and so on. Traditional Chinese medicine may have broad prospects. The lower limb negative pressure-atmospheric pressure recovery tank and the transcutaneous electrical acupoint stimulation play a role in helping the patients to recovery. Also the cognitive and graded activity training needs more attention.