Objective To analyze the vision-related quality of life (VRQL) and mental disorder in patients with primary open angle glaucoma (POAG) patients. Methods Ophthalmic examinations were carried out in 200 POAG participants from May, 2013 to April, 2016. Another 100 volunteers were enrolled as control group. The questionnaires included VRQL, linear rating scale (RS) and Hospital Anxiety and Depression Scale. Results The score of VRQL decreased significantly in the patients group (t=3.998, P<0.001), which mainly showed in dyslexia, dark adaptation, and driving (F>2.523, P<0.05). The RS score significantly decreased in the patients group (t=4.021, P<0.001). The detection rates of anxiety and depression were obviously higher in the patients group than in the control group. Conclusion Patients with POAG have disabilities in mental disorder, self-assessment and VRQL, which need seriously attention.