CJRTP

Chinese Journal of Rehabilitation Theory and Practice >

2017 , Vol. 23 >Issue 2: 162 - 165

DOI: https://doi.org/10.3969/j.issn.1006-9771.2017.02.009

Orginal Article

Effect of Deep-brain Magnetic Stimulation on Learned Helplessness Behavior in Rats with Chronic Restrained Stress

  • LIU Bo ,
  • ZHANG Pan ,
  • LI Da ,
  • YANG Yu-tao ,
  • ZHENG Yun-feng ,
  • XU Zhi-qing
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  • 1. Department of Neurobiology, Capital Medical University, Beijing 100069, China;
    2. Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China;
    3. Beijing Aldans Bio-tech Co., Ltd., Beijing 100044, China

Received date: 2016-09-23

  Revised date: 2016-12-05

  Online published: 2017-03-06

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Abstract

Objective To explore the curative effect of deep-brain magnetic stimulation (DMS) on learned helplessness behavior in the chronic restrained stress (CRS) rat model. Methods Twenty-nine Sprague-Dawley rats were randomly divided into control group (n=8) and CRS group (n=21). CRS group was exerted chronic restrained stress, while the control group did not receive any stress, for three weeks. Then learned helplessness behavior was tested using Forced Swimming Test (FST) and the hopeless rats of the CRS group were divided randomly into sham group (n=6), DMS group (n=8) and citalopram group (n=7), that received corresponding treatment respectively. They were evaluated with FST again after one-week treatment. Results The immobile time in FST was longer in CRS group than in the control group after three-week stress (F=11.260, P=0.002). After one-week treatment, no significant improvement was found in the citalopram group (F=1.565, P=0.235), however, the immobile time in DMS group decreased (F=6.277, P=0.025), and was shorter than that in the sham group (F=5.560, P=0.036). Conclusion CRS could result in learned helplessness behavior, which could be alleviated with one-week DMS.

Key words： chronic restrained stress; learned helplessness behavior; deep-brain magnetic stimulation; hopelessness; suicide; depression; rats

Cite this article

LIU Bo , ZHANG Pan , LI Da , YANG Yu-tao , ZHENG Yun-feng , XU Zhi-qing . Effect of Deep-brain Magnetic Stimulation on Learned Helplessness Behavior in Rats with Chronic Restrained Stress[J]. Chinese Journal of Rehabilitation Theory and Practice, 2017 , 23(2) : 162 -165 . DOI: 10.3969/j.issn.1006-9771.2017.02.009

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