ObjectiveTo observe the effects of mind-regulating brain-developing acupoint magnetic therapy in patients with mild cognitive impairment (MCI). MethodsFrom May to October, 2015, 60 patients with MCI were randomly divided into control group (n=30) and observation group (n=30). The control group received magnetic therapy on Yangming meridians, and the observation group received magnetic therapy on mind-regulating brain-developing acupoints, for two months. They were assessed with Montreal Cognitive Assessment (MoCA), digit-span and digit symbol of Wechsler Adult Intelligence Scale (WAIS). ResultsAfter treatment, the scores of MoCA, digit-span and digit symbol of WAIS significantly increased in the observation group (t>4.858, P<0.001), and were higher than that in the control group (t>2.188, P<0.05), however, only the scores of MoCA and digit symbol of WAIS significantly increased in the control group (t>5.527, P<0.001). The scores of visual space and execution, and delayed recall of MoCA increased in the observation group (t>2.324, P<0.05), and were higher than that in the control group (t>2.262, P<0.05) after treatment, and no significant difference was found in other domains (P>0.05). ConclusionMagnetic therapy on acupoints related with cognition could improve the cognitive function in patients with MCI.
[1] 中华医学会老年医学分会老年神经病学组,老年认知障碍诊治专家共识撰写组. 中国老年人认知障碍诊治流程专家建议[J].中华老年医学杂志, 2014, 33(8): 817-825.
[2] Odawara T. Cautious notification and continual monitoring of patients with mild cognitive impairment [J]. Psychogeriatrics, 2012, 12(2): 131-132.
[3] Chen S, Bai L, Xu M, et al. Multivariate granger causality analysis of acupuncture effects in mild cognitive impairment patients: an fMRI study [J]. Evid Based Complement Alternat Med, 2013, 2013: 127271.
[4] Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment [J]. Intern Med, 2004, 256(3): 240-246.
[5] Portet F, Ousset PJ, Visser PJ, et al. Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease [J]. Neurol Neurosurg Psychiatry, 2006, 77(6): 714-718.
[6] Knopman DS, Petersen RC. Mild cognitive impairment and mild dementia: a clinical perspective [J]. Mayo Clin Proc, 2014, 89(10): 1452-1459.
[7] Tsutsumimoto K, Lee S, Suzuki T, et al. Cognitive impairment and disability in older Japanese adults [J]. PLoS One, 2016, 11(7): e0158720.
[8] Eshkoor SA, Hamid TA, Mun CY, et al. Mild cognitive impairment and its management in older people [J]. Clin Interv Aging, 2015, 10(10): 687-693.
[9] Petersen RC. Clinical practice: Mild cognitive impairment [J]. N Engl J Med, 2011, 364(23): 2227-2234.
[10] Gauthier S, Reisberg B, Zaudig M, et al. Mild cognitive impairment [J]. Lancet, 2006, 367(9518): 1262-1270.
[11] Petersen RC, Caracciolo B, Brayne C, et al. Mild cognitive impairment: a concept in evolution [J]. J Intern Med, 2014, 275(3): 214-228.
[12] Zhou L, Zhang YL, Cao HJ, et al. [Treating vascular mild cognitive impairment by acupuncture: a systematic review of randomized controlled trials] [J]. [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2013, 33(12): 1626-1630.
[13] Leung AW, Lam LC, Kwan AK, et al. Electroacupuncture for older adults with mild cognitive impairment: study protocol for a randomized controlled trial [J]. Trials, 2015, 16: 232-236.
[14] Jiang D, Chu X, Hu L, et al. Yizhi Xingnao prescription improves the cognitive function of patients after a transient ischemic attack [J]. Neural Regen Res, 2012, 7(6): 434-439.
[15] Chen S, Xu M, Li H, et al. Acupuncture at the Taixi (KI3) acupoint activates cerebral neurons in elderly patients with mild cognitive impairment [J]. Neural Regen Res, 2014, 9(11): 1163-1168.
[16] 陈玲,李西亮,张月,等. 针刺在血管性认知障碍治疗中的应用概况[J]. 中医药临床杂志, 2013, 25(9): 817-819.
[17] 杨贞,沃兴德. 磁疗法的临床研究进展[J]. 现代中西医结合杂志, 2007, 16(24): 3608-3610.
[18] 车晓艳,濮红萍,王晓翠,等. 穴位按压联合磁贴法改善晚期胃肠道肿瘤患者生活质量的临床观察[J]. 中国中西医结合杂志, 2014, 34(8): 952-955.
[19] 陈志霞,王健波,吴克明,等. 耳穴配合穴位磁贴对轻中度高血压患者生活质量的影响[J]. 中西医结合心脑血管病杂志, 2015, 13(1): 78-80.
[20] 许新霞,焦伟,韩麦鲜. 磁片贴压头部穴位治疗中风后抑郁80例疗效观察[J]. 光明中医, 2012, 27(10): 2035-2037.
[21] 阙艳,郑粤文,李拥彬. 刺血加穴位磁疗治疗难治性高血压20例[J]. 中国中医药现代远程教育, 2015, 13(15): 65-66.
[22] 郭文海,祝鹏宇,卫彦,等. 原络通经针法对轻度认知障碍患者记忆影响的临床研究[J]. 针灸临床杂志, 2011, 27(11): 4-6.
[23] 赵明星,李亚明. 轻度认知障碍中医证素分布规律的文献研究[J]. 中华中医药学刊, 2012, 30(4): 825-827.
[24] 陈正威,张璞,恽晓平. 工作记忆训练对脑卒中患者大脑功能激活的影响[J]. 中国康复理论与实践, 2015, 21(8): 929-933.
[25] Lie CH, Specht K, Marshall JC, et al. Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test [J]. Neuroimage, 2006, 30(3): 1038-1049.
[26] 张慧丽,恽晓平,郭华珍,等. 脑损伤患者的执行功能损害[J]. 中国康复理论与实践, 2016, 22(5): 504-507.
[27] 尹宁,徐桂芝,于洪丽. 磁刺激穴位对大脑功能网络的影响[J]. 中国生物医学工程学报, 2013, 32(2): 184-190.
[28] 陈尚杰,朱芬,彭旭明,等.刺激健康青年太溪穴和假穴的功能磁共振研究[J]. 中国康复, 2009, 24(5): 308-309.
[29] 王单,吕敦召,帅记焱,等. 应用静息态功能磁共振技术研究太溪穴对老年人脑网络的影响[J]. 中国老年学杂志, 2016, 36(12): 2986-2988.
