ObjectiveTo explore the association of ubiquitin-specific proteases 24 (USP24) gene polymorphisms with susceptibility to sporadic Parkinson's disease (PD) in the Han Guangdong population. MethodsFrom August, 2006 to January, 2014, single nucleotide polymorphisms (SNPs) of rs12138592 and rs6671533 in the intron region of USP24 were genotyped in 200 patients with sporadic PD and 200 healthy controls using the SNaPshot technique. ResultsThere was significant difference in the allele and genotype frequency of rs12138592 between the patients and the controls (P<0.01), and no significant difference was found in the allele and genotype frequency of rs6671533 (P>0.05). ConclusionThe SNP of rs12138592 in the intron region of USP24 is associated with the susceptibility to sporadic PD in the Han Guangdong population, and the A allele may contribute a protective roles to PD.
LIN Zhi-jun
,
CHEN Yu-sen
,
ZHONG Wang-tao
,
LIU Zhou
,
XIAN Wen-chuan
,
CHEN Xiao-yi
,
ZHAO Bin
. Association between Ubiquitin-specific Proteases 24 Gene Polymorphisms and Sporadic Parkinson's Disease in the Han Guangdong Population[J]. Chinese Journal of Rehabilitation Theory and Practice, 2017
, 23(3)
: 345
-348
.
DOI: 10.3969/j.issn.1006-9771.2017.03.021
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