Application of Neural Tract Tracing Techniques in Study of Spinal Cord Injury and Regeneration (review)

  • LI Wan-yue ,
  • DING Yu-meng ,
  • WANG Xi
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  • 1. First Pragade of Undergraduates, Fourth Military Medical University, Xi'an, Shaanxi 710032, China;
    2. Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi 710032, China

Received date: 2016-10-18

  Revised date: 2016-11-08

  Online published: 2017-06-27

Abstract

Spinal cord injury is one of the important field of neuroscience, and neural tract tracing techniques are important research tools. The neural fiber types in the spinal cord are complex, and there are some difference in structures between human beings and animals. This article reviewed different types of neural fibers closely related with spinal cord injury and regeneration, the difference between human beings and animals, and the application of neural tract tracing techniques in the study of spinal cord injury and regeneration.

Cite this article

LI Wan-yue , DING Yu-meng , WANG Xi . Application of Neural Tract Tracing Techniques in Study of Spinal Cord Injury and Regeneration (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2017 , 23(6) : 657 -661 . DOI: 10.3969/j.issn.1006-9771.2017.06.008

References

[1] Schwab JM, Brechtel K, Mueller CA, et al. Experimental strategies to promote spinal cord regeneration–an integrative perspective [J]. Prog Neurobiol, 2006, 78(2): 91-116.
[2] Fakhoury M. Spinal cord injury: overview of experimental approaches used to restore locomotor activity [J]. Rev Neurosci, 2015, 26(4): 397-405.
[3] 李建军,周红俊,洪毅,等. 2002年北京市脊髓损伤发病率调查[J]. 中国康复理论与实践, 2004, 10(7): 412-413.
[4] Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS [J]. Neuron, 2012, 74(5): 777-791.
[5] Okano H. Strategic approaches to regeneration of a damaged central nervous system [J]. Cornea, 2011, 30(Suppl 1): S15-S18.
[6] Lanciego JL, Wouterlood FG. A half century of experimental neuroanatomical tracing [J]. J Chem Neuroanat, 2011, 42(3): 157-183.
[7] Wouterlood FG. Laser Scanning Microscopy and Quantitative Image Analysis of Neuronal Tissue [M]. New York: Humanna Press, 2014: 51-86.
[8] Wouterlood FG, Bloem B, Mansvelder HD, et al. A fourth generation of neuroanatomical tracing techniques: exploiting the offspring of genetic engineering [J]. J Neurosci Methods, 2014, 235: 331-348.
[9] Nauta WJ. Selective silver impregnation of degenerating axons in the central nervous system [J]. Stain Technol, 1952, 27(3): 175-179.
[10] Fink RP, Heimer L. Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system [J]. Brain Res, 1967, 4(4): 369-374.
[11] 朱贺,徐丽丽,李丽,等. 常用神经示踪剂及其示踪特点研究进展[J]. 神经损伤与功能重建, 2009, 4(4): 288-290
[12] Roozbehi A, Joghataei MT, Bakhtiyari M, et al. Age-associated changes on axonal regeneration and functional outcome after spinal cord injury in rats [J]. Acta Med Iran, 2015, 53(5): 281-286.
[13] Hanna A, Thompson DL, Hellenbrand DJ, et al. Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury [J]. J Neurosci Res, 2016, 94(7): 645-652.
[14] Dengler-Crish CM, Smith MA, Inman DM, et al. Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma [J]. Front Neurosci, 2014, 8: 290
[15] Kikukawa S, Kawaguchi S, Mizoguchi A, et al. Regeneration of dorsal column axons after spinal cord injury in young rats [J]. Neurosci Lett, 1998, 249(2-3): 135-138.
[16] Bayless DW, Daniel JM. Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control [J]. Neuroscience, 2015, 300: 286-296
[17] Reiner A, Veenman CL, Medina L, et al. Pathway tracing using biotinylated dextran amines [J]. J Neurosci Methods, 2000, 103(1): 23-37.
[18] Lai BQ, Qiu XC, Zhang K, et al. Cholera toxin B subunit shows transneuronal tracing after injection in an injured sciatic nerve [J]. PLoS One, 2015, 10(12): e0144030
[19] Buffelli M, Burgess RW, Feng G, et al. Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition [J]. Nature, 2003, 424(6947): 430-434.
[20] Bareyre FM, Kerschensteiner M, Misgeld T, et al. Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury [J]. Nat Med, 2005, 11(12):1355-1360.
[21] Willenberg R, Steward O. Non-specific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration [J]. J Comp Neurol, 2015, 523(18): 2665-2682.
[22] Rosenzweig ES, Brock JH, Culbertson MD, et al. Extensive spinal decussation and bilateral termination of cervical corticospinal projections in Rhesus monkeys [J]. J Comp Neurol, 2009, 513(2): 151-163.
[23] Weidner N, Ner A, Salimi N, et al. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury [J]. Proc Natl Acad Sci U S A, 2001, 98(6): 3513-3518.
[24] Danilov CA, Steward O. Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice [J]. Exp Neurol, 2015, 266: 147-160.
[25] Freund P, Schmidlin E, Wannier T, et al. Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates-re-examination and extension of behavioral data [J]. Eur J Neurosci, 2009, 29(5): 983-996.
[26] Hoogewoud F, Hamadjida A, Wyss AF, et al. Comparison of functional recovery of manual dexterity after unilateral spinal cord lesion or motor cortex lesion in adult macaque monkeys [J]. Front Neurol, 2013, 4: 101.
[27] Nakagawa H, Ninomiya1 T, Yamashita T, et al. Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques [J]. Sci Rep, 2015, 5: 11986.
[28] Wannier-Morino P, Schmidlin E, Freund P, et al. Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: effects of an antibody treatment neutralizing Nogo-A [J]. Brain Res, 2008, 1217: 96-109.
[29] Morris R, Tosolini AP, Goldstein JD, et al. Impaired arpeggio movement in skilled reaching by rubrospinal tract lesions in the rat: a behavioral/anatomical fractionation [J]. J Neurotrauma, 2011, 28(12): 2439-2451.
[30] Yang HS, Kwon HG, Hong JH, et al. The rubrospinal tract in the human brain: diffusion tensor imaging study [J]. Neurosci Lett, 2011, 504(1):45-48.
[31] Mestre H, Ramirez M, Garcia E, et al. Lewis, Fischer 344, and Sprague-Dawley rats display differences in lipid peroxidation, motor recovery, and rubrospinal tract preservation after spinal cord injury [J]. Front Neurol, 2015, 6: 108.
[32] Weishaupt N, Hurd C, Wei DZ, et al. Reticulospinal plasticity after cervical spinal cord injury in the rat involves withdrawal of projections below the injury [J]. Exp Neurol, 2013, 247: 241-249.
[33] Filli L, Engmann AK, Weinmann O, et al. Bridging the gap: a reticulo-propriospinal detour bypassing an incomplete spinal cord injury [J]. J Neurosci, 2014, 34(40): 13399-13410.
[34] Bonner JF, Connors TM, Silverman WF, et al. Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord [J]. J Neurosci, 2011, 31(12): 4675-4686.
[35] Hoeber L, Trolle C, Konig N, et al. Human embryonic stem cell derived progenitors assist functional sensory axon regeneration after dorsal root avulsion injury [J]. Sci Rep, 2015, 5: 10666.
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