Objective To analyze functioning and disability, unmet needs and the service for people with disabilities in Shenzhen, Guangdong, China. Methods Based on International Classification of Functioning, Disability and Health (ICF) and World Report on Disability, the theoretical framework had been constructed, and the unmet needs and service status for people with disabilities in Shenzhen in 2015 had been statistically analyzed. Results For the statistics of disability by categories, physical disability composed of 42.5%, speech disability composed of 1.5%; people with severe and extremely severe disabilities composed of 52.8%; Futian District composed of 19.7%, Yantian District composed of 2.2%; people aged 0 to 18 years composed of 17.4%, and people aged over 60 years (27.0%) were the larger group. For the unmet needs of people with disabilities, 25% needed rehabilitation therapy, 18.8% needed functional training, 23.2% needed assistive devices, and 32.9% had no need. For rehabilitation sevice in Shenzhen, 24.4% received rehabilitation therapy, 17.4% received functional training, 20.4% received assistive devices, and 37.6% did not receive any service. For the barrier-free reconstruction, 4.6% needed bathroom reconstruction, and 0.7% needed internet access screen software. Conclusion The status of functioning and disability, unmet needs and service development of rehabilitation in Shenzhen had been analyzed. There was still a gap between unmet needs and services of rehabilitation. It recommended to construct precise services delivery based on unmet needs, improve the full coverage and quality of service of rehabilitation.