Effects of High Intensity Interval Training on Type 2 Diabetes Mellitus: A Meta-analysis

  • CHEN Bing-lin ,
  • GUO Jia-bao
Expand
  • 1. Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, China;
    2. Xuzhou Medical University, Xuzhou, Jiangsu 221004, China;
    3. Shanghai University of Sport, Shanghai 200438, China

Received date: 2017-12-19

  Revised date: 2018-01-30

  Online published: 2018-03-27

Supported by

Supported by Zhejiang Education Department Research Project (General) (No. Y201635345)

Abstract

Objective To evaluate the effect of high intensity interval training (HIIT) on type 2 diabetes mellitus (T2DM). Methods Published articles from the earliest date available to September the first, 2016 were recalled from PubMed, Embase, Cochrane Library, EBSCO, Web of Science, CNKI and CBM Database. Two reviewers selected independently the randomized controlled trials (RCTs) about HIIT for patients with T2DM, and extracted data independently and analyzed with RevMan 5.3. Results Eight trials that represented 275 participants were evaluated. HIIT could significantly improve glycated hemoglobin (SMD=-0.72, 95%CI -1.39~-0.04, P=0.04) and body mass index (MD=-0.60, 95%CI -1.03~-0.18, P=0.005) more than the control group, but no difference was found in the levels of fasting blood-glucose, fasting insulin, insulin resistance, and indexes of blood fat, body mass, body fat mass and waist circumference (P>0.05).Conclusion There is no evidence showed that HIIT is more effective on blood glucose, blood fat and body composition in the patients with T2DM, which needs further research.

Cite this article

CHEN Bing-lin , GUO Jia-bao . Effects of High Intensity Interval Training on Type 2 Diabetes Mellitus: A Meta-analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2018 , 24(3) : 353 -362 . DOI: 10.3969/j.issn.1006-9771.2018.03.020

References

[1] Xu Y, Wang LM, He J, et al.Prevalence and control of diabetes in Chinese adults[J]. JAMA, 2013, 310(9): 948-959.
[2] World Health Organization. Global Report on Diabetes. 2016 [EB/OL]. [2017-11-01]. http://www.who.int/diabetes/global-report.
[3] Colberg SR, Sigal RJ, Fernhall B, et al.Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: Joint Position Statement[J]. Diabetes Care, 2010, 33(12): e147-e167.
[4] Nery C, Moraes SRA, Novaes KA, et al.Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2 diabetes mellitus: a meta-analysis[J]. Braz J Phys Ther, 2017, 21(6): 400-415.
[5] Grace A, Chan E, Giallauria F, et al.Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis[J]. Cardiovasc Diabetol, 2017, 16(1): 37.
[6] Fox AM, Mann DM, Ramos MA, et al.Barriers to physical activity in East Harlem, New York[J]. J Obes, 2012, doi: 10.1155/2012/719140.
[7] Rye JA, Rye SL, Tessaro I, et al.Perceived barriers to physical activity according to stage of change and body mass index in the West Virginia wisewoman population[J]. Womens Health Issues, 2009, 19(2): 126-134.
[8] 中华医学会糖尿病分会. 中国2型糖尿病防治指南(2013版)[J]. 中华糖尿病杂志, 2014, 6(7): 447-488.
[9] 刘瑞东,曹春梅,刘建秀,等. 高强度间歇训练的应用及其适应机制[J]. 体育科学, 2017, 37(7): 73-82.
[10] Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans [EB/OL]. (2008-10-01) [2015-09-20]. http://www.health.gov/paguidelines.
[11] 王娟,王正珍,罗曦娟,等. 高强度间歇训练降低2型糖尿病和糖尿病前期人群心血管疾病风险的有效性和安全性[J]. 中国运动医学杂志, 2016, 35(6): 561-567.
[12] 尚画雨,张丹,王瑞元,等. 高强度间歇训练对糖尿病作用效果研究进展[J]. 中国康复医学杂志, 2014, 29(8): 793-798.
[13] 杨京辉,汪亚群,楼青青,等. 高强度间歇运动对糖尿病前期患者糖脂代谢的影响[J]. 中国康复医学杂志, 2017, 32(8): 907-911, 937.
[14] American Diabetes Association.Standards of Medical Care in Diabetesd-2016 Abridged for Primary Care Providers[J]. Clin Diabetes, 2016, 34(1): 3-21.
[15] Higgins JPT, Green S.Cochrane Handbook for Systematic Reviews of Interventions[M]. Version 5.1.0. Cochrane Collaboration, 2011.
[16] Guyatt GH, Oxman AD, Vist GE, et al.GRADE: an emerging consensus on rating quality of evidence and strength of recommendations[J]. BMJ, 2008, 336(7650): 924-926.
[17] Cassidy S, Thoma C, Hallsworth K, et al.High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial[J]. Diabetologia, 2016, 59(1): 56-66.
[18] Karstoft K, Winding K, Knudsen SH, et al.Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial[J]. Diabetologia, 2014, 57(10): 2081-2093.
[19] Robinson E, Durrer C, Simtchouk S, et al.Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes[J]. J Appl Physiol (1985), 2015, 119(5): 508-516.
[20] Alvarez C, Ramirez-Campillo R, Martinez-Salazar C, et al.Low-volume high-intensity interval training as a therapy for type 2 diabetes[J]. Int J Sports Med, 2016, 37(9): 723-729.
[21] Mitranun W, Deerochanawong C, Tanaka H, et al.Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients[J]. Scand J Med Sci Sports, 2014, 24(2): e69-e76.
[22] Hollekim-Strand SM, Bjørgaas MR, Albrektsen G, et al.High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial[J]. J Am Coll Cardiol, 2014, 64(16): 1758-1760.
[23] Maillard F, Rousset S, Pereira B, et al.High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes[J]. Diabetes Metab, 2016, 42(6): 433-441.
[24] Terada T, Friesen A, Chahal BS, et al.Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes[J]. Diabetes Res Clin Pract, 2013, 99(2): 120-129.
[25] Hauk L.Preventing CVD in adults with type 2 diabetes mellitus: an update from the AHA and ADA[J]. Am Fam Physician, 2016, 93(3): 232-233.
[26] Miele EM, Headley SAE.The effects of chronic aerobic exercise on cardiovascular risk factors in persons with diabetes mellitus[J]. Curr Diab Rep, 2017, 17(10): 97.
[27] American Diabetes Association.Classification and Diagnosis of Diabetes[J]. Diabetes Care, 2016, 39(1): 13-22.
[28] Little JP, Safdar A, Bishop D, et al.An acute bout of high- intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle[J]. Am J Physiol Regul Integr Comp Physiol, 2011, 300(6): 1303-1310.
[29] Hood MS, Little JP, Tarnopolsky MA, et al.Low-volume interval training improves muscle oxidative capacity in sedentary adults[J]. Med Sci Sports Exerc, 2011, 43(10): 1849-1856.
[30] Tjønna AE, Stølen TO, Bye A, et al.Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents[J]. Clin Sci (Lond), 2009, 116(4): 317-326.
[31] Trilk JL, Singhal A, Bigelman KA, et al.Effect of sprint interval training on circulatory function during exercise in sedentary, overweight/obese women[J]. Eur J Appl Physiol, 2011, 111(8): 1591-1597.
[32] Dias KA, Ingul CB, Tjønna AE, et al.Effect of high-intensity interval training on fitness, fat mass and cardiometabolic biomarkers in children with obesity: a randomised controlled trial[J]. Sports Med, 2018, 48(3): 733-746.
[33] Colberg SR, Sigal RJ, Fernhall B, et al.Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement[J]. Diabetes Care, 2010, 33(12): 2692-2696.
[34] Hu FB, Stampfer MJ, Solomon C, et al.Physical activity and risk for cardiovascular events in diabetic women[J] Ann Intern Med, 2001, 134(2): 96-105.
[35] Kannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study[J]. Diabetes Care, 1979, 2(2): 120-126.
[36] Ramos JS, Dalleck LC, Borrani F, et al.Low-volume high-intensity interval training is sufficient to ameliorate the severity of metabolic syndrome[J]. Metab Syndr Relat Disord, 2017, 15(7): 319-328.
[37] Wewege M, van den Berg R, Ward RE, et al. The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis[J]. Obes Rev, 2017, 18(6): 635-646.
[38] Keating SE, Johnson NA, Mielke GI, et al.A systematic review and meta-analysis of interval training versus moderate-intensity continuous training on body adiposity[J]. Obes Rev, 2017, 18(8): 943-964.
Outlines

/