Objective To summarize the effect of individualized rehabilitation nursing combined with music therapy on one patient with severe pneumonia complicated with multiple organ failure.Methods Based on the comprehensive evaluation of patients, the rehabilitation programs including critical care, personalized rehabilitation care and personalized music therapy were established, and the corresponding nursing measures and muscle training were implemented.Results After careful nursing, music therapy and muscle training for seven days, the score of Acute Physiology and Chronic Health Evaluation Scoring System (APACHE II) decreased from 28 to 14; the upper limb muscle strength increased; the score of Self-rating Anxiety Scale (SAS) decreased from 71 to 52; the score of Fugl-Meyer Assessment (FMA) increased from 38 to 80; and modified Barthel index increased from 0 to 55.Conclusion Personalized rehabilitation care could effectively promote the recovery, and increase the activities of daily living of patients with severe pneumonia complicated with multiple organ failure.