Objective To explore the rehabilitation and outcome of motor neuron syndrome and Sjögren's syndrome. Methods A patient with motor neuron syndrome and Sjögren's syndrome was reviewed. Results The patient expressed progressive quadriparesis and slurred speech. Electromyogramphy displayed upper and lower motor neuron damage. Sonography showed diffuse lesions in parotid gland and submandibular gland. Laboratory tests displayed markedly elevated levels of SSA and Ro52 antibodies. After a course of intravenous immunoglobulin (IVIG) and four weeks of comprehensive rehabilitation, the patient improved in terms of speech, muscle strength, balance, posture control and activities of daily living. She failed to achieve further improvement after another IVIG and glucocorticoid two months later, but fortunately her symptoms did not deteriorate. Conclusion The patient with motor neuron syndrome and Sjögren's syndrome might benefit from IVIG and appropriate rehabilitation.
MI Hai-xia
,
DU Xiao-xia
. Rehabilitation for Motor Neuron Syndrome and Sjögren's Syndrome: A Case Report[J]. Chinese Journal of Rehabilitation Theory and Practice, 2018
, 24(5)
: 585
-591
.
DOI: 10.3969/j.issn.1006-9771.2018.05.019
[1] Moutsopoulos HM.Sjögren's syndrome: autoimmune epithelitis[J]. Clin Immunol Immunopathol, 1994, 72(2): 162-165.
[2] Alegria G, Guellec D, Mariette X, et al.Epidemiology of neurological manifestations in Sjögren's syndrome: data from the French ASSESS Cohort[J]. RMD Open, 2016, 2(1): e000179.
[3] Jamilloux Y, Magy L, Hurtevent J, et al.Immunological profiles determine neurological involvement in Sjögren's syndrome[J]. Eur J Intern Med, 2014, 25(2): 177-181.
[4] Delalande S, de Seze J, Fauchais AL, et al. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients[J]. Medicine (Baltimore), 2004, 83(5): 280-291.
[5] 廖琴,樊东升. 肌萎缩侧索硬化伴干燥综合征四例临床分析[J]. 中华神经科杂志, 2012, 45(7): 467-470.
[6] Hagiwara K, Murai H, Ochi H, et al.Upper motor neuron syndrome associated with subclinical Sjögren's syndrome[J]. Intern Med, 2008, 47(11): 1047-1051.
[7] Salachas F, Lafitte C, Chassande B, et al.Motor neuron disease mimicking amyotrophic lateral sclerosis or primary lateral sclerosis in primary Sjogren's syndrome[J]. Neurology, 1998, 50(4): A31.
