Effect of Aerobic Exercise on Behavioral Function in Rats with Cerebral Small Vessel Disease

  • WANG Ru ,
  • LIU Nan ,
  • LI Wei-ping ,
  • ZHAO Hong-yi ,
  • DU Ju-mei ,
  • HUANG Yong-hua
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  • 1.Department of Neurology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China
    2.Department of Neurology, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China

Received date: 2018-11-26

  Revised date: 2019-01-16

  Online published: 2019-04-02

Supported by

National Natural Science Foundation of China (Youth) (No. 81601035)

Abstract

Objective To explore the effect of aerobic exercise on behavioral function in rats with cerebral small vessel disease and its mechanism. Methods Eight-week-old male Sprague-Dawley rats were randomly divided into sham group (n = 16), model group (n = 16) and swimming group (n = 16). The model was developed with bilateral common carotid artery ligation. They were assessed with burrowing test after four weeks of swimming exercise. The levels of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) protein in hippocampus were detected with Western blotting. The development of dendrites and synaptic spines in hippocampal neurons was observed with Golgi staining. The expression of Ki67, doublecortin (DCX) and Neun in hippocampal dentate gyrus was detected with immunofluorescence. Results Compared with the model group, the burrowing ability improved in the swimming group (P < 0.05), with increase of levels of BDNF and TrkB in hippocampus (P < 0.05), Ki67/DCX and Neun positive cells in hippocampal dentate gyrus (P < 0.05), and extension of dendrites and length of synaptic spine in hippocampal neurons (P < 0.05). Conclusion Aerobic exercise may promote the proliferation and differentiation of hippocampal neurons through BDNF/TrkB signaling pathway, expression of Ki67/DCX and Neun and development of hippocampal neurons, to improve behavioral function in rats with cerebral small vessel disease.

Cite this article

WANG Ru , LIU Nan , LI Wei-ping , ZHAO Hong-yi , DU Ju-mei , HUANG Yong-hua . Effect of Aerobic Exercise on Behavioral Function in Rats with Cerebral Small Vessel Disease[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(3) : 249 -254 . DOI: 10.3969/j.issn.1006-9771.2019.03.001

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