Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)

  • LEI Xing-xing ,
  • GU Bin ,
  • SONG Lu-ping
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  • 1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
    2.Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
    3.Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China

Received date: 2018-05-20

  Revised date: 2018-06-22

  Online published: 2019-04-02

Supported by

National Key Research and Development Program (No. 2016YFF0201002) and National Special Fund Projects of Basic Research of Public Benefits for Institutes at Central Governmental Level (No. 2016CZ-6)

Abstract

Aging leads to cognitive decline, including memory, attention, language and execution. Alzheimer's disease (AD) is a progressive neurodegenerative disorder closely related to age. Decreased cognitive function is one of its core symptoms. Transcranial direct current stimulation (tDCS) has been used in old healthy adults and AD patients to improve aging-related cognitive impairment. tDCS can improve memory (situational memory, semantic memory and working memory), language, error awareness and attentional functions in the old adults, which were influenced by many factors, such as education levels, stimulation parameters and individual task baseline scores, etc. For AD patients, tDCS may improve their cognitive function, which is influenced by the factors as anatomical differences, severity of disease, stimulation parameters and assessment tools, etc. Cognitive training combined with tDCS can further improve cognitive function in old adults and AD patients.

Cite this article

LEI Xing-xing , GU Bin , SONG Lu-ping . Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(3) : 255 -260 . DOI: 10.3969/j.issn.1006-9771.2019.03.002

References

1 CelsisP. Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer's disease? [J]. Ann Med, 2000, 32(1): 6-14.
2 ChristensenP K, DoblhammerP G, RauP R, et al. Ageing populations: the challenges ahead [J]. Lancet, 2009, 374(9696): 1196.
3 MathersC D, StevensG A, BoermaT, et al. Causes of international increases in older age life expectancy [J]. Lancet, 2015, 385(9967): 540-548.
4 AssociationAlzheimer's. 2018 Alzheimer's disease facts and figures [J]. Alzheimers Dement, 2018, 14(3): 367-429.
5 ShafqatS. Alzheimer disease therapeutics: perspectives from developing world [J]. J Alzheimers Dis, 2008, 15(2): 285-287.
6 DedonckerJ, BrunoniA R, BaekenC, et al. A systematic review and meta-analysis of the effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex in healthy and neuropsychiatric samples: influence of stimulation parameters [J]. Brain Stimul, 2016, 9(4): 501-517.
7 GiordanoJ, BiksonM, KappenmanE S, et al. Mechanisms and effects of transcranial direct current stimulation [J]. Dose Response, 2017, 15(1): 1559325816685467.
8 HoffmanR E, CavusI. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders [J]. Am J Psychiatry, 2002, 159(7): 1093.
9 JamilA, BatsikadzeG, KuoH I, et al. Systematic evaluation of the impact of stimulation intensity on neuroplastic after-effects induced by transcranial direct current stimulation [J]. J Physiol, 2017, 595(4): 1273-1288.
10 HoyK E, EmonsonM R, ArnoldS L, et al. Testing the limits: investigating the effect of tDCS dose on working memory enhancement in healthy controls [J]. Neuropsychologia, 2013, 51(9): 1777-1784.
11 MartinsA R, FregniF, SimisM, et al. Neuromodulation as a cognitive enhancement strategy in healthy older adults: promises and pitfalls [J]. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 2017, 24(2): 158-185.
12 Fl?elA, SuttorpW, KohlO, et al. Non-invasive brain stimulation improves object-location learning in the elderly [J]. Neurobiol Aging, 2012, 33(8): 1682.
13 SandriniM, ManentiR, BrambillaM, et al. Older adults get episodic memory boosting from noninvasive stimulation of prefrontal cortex during learning [J]. Neurobiol Aging, 2016, 39: 210-216.
14 SandriniM, BrambillaM, ManentiR, et al. Noninvasive stimulation of prefrontal cortex strengthens existing episodic memories and reduces forgetting in the elderly [J]. Front Aging Neurosci, 2014, 6: 289.
15 ManentiR, BrambillaM, PetesiM, et al. Enhancing verbal episodic memory in older and young subjects after non-invasive brain stimulation [J]. Front Aging Neurosci, 2013, 5: 49.
16 RossL A, McCoyD, CoslettH B, et al. Improved proper name recall in aging after electrical stimulation of the anterior temporal lobes [J]. Front Aging Neurosci, 2011, 3: 16.
17 KirovaA M, BaysR B, LagalwarS. Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease [J]. Biomed Res Int, 2015, 2015(6): 1-9.
18 SummersJ J, KangN, CauraughJ H. Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta-analysis [J]. Ageing Res Rev, 2016, 25: 42-54.
19 PinalD, ZurronM, DiazF, et al. Stuck in default mode: inefficient cross-frequency synchronization may lead to age-related short-term memory decline [J]. Neurobiol Aging, 2015, 36(4): 1611-1618.
20 BerryhillM E, JonesK T. tDCS selectively improves working memory in older adults with more education [J]. Neurosci Lett, 2012, 521(2): 148-151.
21 CabezaR, AndersonN D, LocantoreJ K, et al. Aging gracefully: compensatory brain activity in high-performing older adults [J]. Neuroimage, 2002, 17(3): 1394-1402.
22 DavisS W, DennisN A, DaselaarS M, et al. Que PASA? The posterior-anterior shift in aging [J]. Cereb Cortex, 2008, 18(5): 1201-1209.
23 BucknerR L, Andrews-HannaJ R, SchacterD L. The brain's default network: anatomy, function, and relevance to disease [J]. Ann N Y Acad Sci, 2008, 1124(1): 1-38.
24 KochW, TeipelS, MuellerS, et al. Effects of aging on default mode network activity in resting state fMRI: does the method of analysis matter? [J]. Neuroimage, 2010, 51(1): 280-287.
25 GradyC L, ProtznerA B, KovacevicN, et al. A multivariate analysis of age-related differences in default mode and task positive networks across multiple cognitive domains [J]. Cereb Cortex, 2010, 20(6): 1432.
26 MeinzerM, LindenbergR, AntonenkoD, et al. Anodal transcranial direct current stimulation temporarily reverses age-associated cognitive decline and functional brain activity changes [J]. J Neurosci, 2013, 33(30): 12470-12478.
27 TuschE S, AlperinB R, RyanE, et al. Changes in neural activity underlying working memory after computerized cognitive training in older adults [J]. Front Aging Neurosci, 2016, 8: e102710.
28 van DinterenR, ArnsM, JongsmaM L, et al. Combined frontal and parietal P300 amplitudes indicate compensated cognitive processing across the lifespan [J]. Front Aging Neurosci, 2014, 6: 294.
29 CesponJ, RodellaC, RossiniP M, et al. Anodal transcranial direct current stimulation promotes frontal compensatory mechanisms in healthy elderly subjects [J]. Front Aging Neurosci, 2017, 9: 420.
30 SantarnecchiE, BremA K, LevenbaumE, et al. Enhancing cognition using transcranial electrical stimulation [J]. Curr Opin Behav Sci, 2015, 4: 171-178.
31 PassowS, ThurmF, LiS C. Activating developmental reserve capacity via cognitive training or non-invasive brain stimulation: potentials for promoting fronto-parietal and hippocampal-striatal network functions in old age [J]. Front Aging Neurosci, 2017, 9: 33.
32 ElmasryJ, LooC, MartinD. A systematic review of transcranial electrical stimulation combined with cognitive training [J]. Restor Neurol Neurosci, 2015, 33(3): 263-278.
33 PrehnK, FloelA. Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS [J]. Front Cell Neurosci, 2015, 9: 355.
34 AuJ, KarstenC, BuschkuehlM, et al. Optimizing transcranial direct current stimulation protocols to promote long-term learning [J]. J Cogn Enhanc, 2017, 1(1): 65-72.
35 MartinD M, LiuR, AlonzoA, et al. Can transcranial direct current stimulation enhance outcomes from cognitive training? A randomized controlled trial in healthy participants [J]. Int J Neuropsychopharmacol, 2013, 16(9): 1927-1936.
36 ParkS H, SeoJ H, KimY H, et al. Long-term effects of transcranial direct current stimulation combined with computer-assisted cognitive training in healthy older adults [J]. Neuroreport, 2014, 25(2): 122-126.
37 IachiniI, IavaroneA, SeneseVP, et al. Visuospatial memory in healthy elderly, AD and MCI: a review [J]. Curr Aging Sci, 2009, 2(1): 43-59.
38 AntonenkoD, KulzowN, SousaA, et al. Neuronal and behavioral effects of multi-day brain stimulation and memory training [J]. Neurobiol Aging, 2018, 61: 245-254.
39 KulzowN, Cavalcanti de SousaA V, CesarzM, et al. No effects of non-invasive brain stimulation on multiple sessions of object-location-memory training in healthy older adults [J]. Front Neurosci, 2017, 11: 746.
40 HorvathJ C, ForteJ D, CarterO. Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS) [J]. Brain Stimul, 2015, 8(3): 535-550.
41 WangJ X, VossJ L. Long-lasting enhancements of memory and hippocampal-cortical functional connectivity following multiple-day targeted noninvasive stimulation [J]. Hippocampus, 2015, 25(8): 877-883.
42 FertonaniA, BrambillaM, CotelliM, et al. The timing of cognitive plasticity in physiological aging: a tDCS study of naming [J]. Front Aging Neurosci, 2014, 6: 131.
43 MeinzerM, LindenbergR, SiegM M, et al. Transcranial direct current stimulation of the primary motor cortex improves word-retrieval in older adults [J]. Front Aging Neurosci, 2014, 6: 253.
44 HartyS, RobertsonI H, MiniussiC, et al. Transcranial direct current stimulation over right dorsolateral prefrontal cortex enhances error awareness in older age [J]. J Neurosci, 2014, 34(10): 3646-3652.
45 LearmonthG, ThutG, BenwellC S, et al. The implications of state-dependent tDCS effects in aging: Behavioural response is determined by baseline performance [J]. Neuropsychologia, 2015, 74: 108-119.
46 KimY J. Transcranial direct current stimulation as an alternative treatment in patients with Alzheimer's disease [J]. Brain Neurorehabil, 2017, 10(1): e4.
47 梁宝今,梁涛,王晓文,等. 经颅直流电刺激对阿尔茨海默病认知功能的研究进展[J]. 中国康复医学杂志, 2017, 32(8): 959-962.
48 张凤霞,郑彩霞,黄晓琳. 经颅直流电刺激用于治疗阿尔茨海默病的研究进展[J]. 中国康复医学杂志, 2017, 32(9): 1068-1073.
49 C R JrJack. Alliance for aging research AD biomarkers work group: structural MRI [J]. Neurobiol Aging, 2011, 32(Suppl 1): S48-S57.
50 EichenbaumH. Prefrontal-hippocampal interactions in episodic memory [J]. Nat Rev Neurosci, 2017, 18(9): 547-558.
51 PolaniaR, NitscheM A, PaulusW. Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation [J]. Hum Brain Mapp, 2011, 32(8): 1236-1249.
52 MeinzerM, LindenbergR, PhanM T, et al. Transcranial direct current stimulation in mild cognitive impairment: behavioral effects and neural mechanisms [J]. Alzheimers Dement, 2015, 11(9): 1032-1040.
53 ElderG J, TaylorJ P. Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias? [J]. Alzheimers Res Ther, 2014, 6(9): 74.
54 BoggioP S, KhouryL P, MartinsD C, et al. Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease [J]. J Neurol Neurosurg Psychiatry, 2009, 80(4): 444-447.
55 BoggioP S, FerrucciR, MameliF, et al. Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease [J]. Brain Stimul, 2012, 5(3): 223-230.
56 FerrucciR, MameliF, GuidiI, et al. Transcranial direct current stimulation improves recognition memory in Alzheimer disease [J]. Neurology, 2008, 71(7): 493-498.
57 KhedrE M, GamalN F, El-FetohN A, et al. A double-blind randomized clinical trial on the efficacy of cortical direct current stimulation for the treatment of Alzheimer's disease [J]. Front Aging Neurosci, 2014, 6: 275.
58 BystadM, RasmussenI D, GronliO, et al. Can 8 months of daily tDCS application slow the cognitive decline in Alzheimer's disease? A case study [J]. Neurocase, 2017, 23(2): 146-148.
59 BystadM, GronliO, RasmussenI D, et al. Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer's disease: a randomized, placebo-controlled trial [J]. Alzheimers Res Ther, 2016, 8(1): 13.
60 LiuC S, RauA, GallagherD, et al. Using transcranial direct current stimulation to treat symptoms in mild cognitive impairment and Alzheimer's disease [J]. Neurodegener Dis Manag, 2017, 7(5): 317-329.
61 LeeM S, LeeS H, MoonE O, et al. Neuropsychological correlates of the P300 in patients with Alzheimer's disease [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 40: 62-69.
62 PedrosoR V, FragaF J, CorazzaD I, et al. P300 latency and amplitude in Alzheimer's disease: a systematic review [J]. Braz J Otorhinolaryngol, 2012, 78(4): 126-132.
63 HsuW Y, KuY, ZantoT P, et al. Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis [J]. Neurobiol Aging, 2015, 36(8): 2348-2359.
64 VanniniP, HanseeuwB, MunroC E, et al. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden [J]. Neurology, 2017, 88(18): 1759-1767.
65 ManentiR, SandriniM, GobbiE, et al. Strengthening of existing episodic memories through non-invasive stimulation of prefrontal cortex in older adults with subjective memory complaints [J]. Front Aging Neurosci, 2017, 9: 401.
66 HampsteadB, GopinathK. Behavioral and fMRI changes associated with combined tDCS and cognitive rehabilitation in a case series of patients with mild cognitive impairment [J]. Clin Neurophysiol, 2013, 124(10): 123-124.
67 PenolazziB, BergamaschiS, PastoreM, et al. Transcranial direct current stimulation and cognitive training in the rehabilitation of Alzheimer disease: a case study [J]. Neuropsychol Rehabil, 2015, 25(6): 799-817.
68 RonceroC, KniefelH, ServiceE, et al. Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer's disease and frontotemporal dementia [J]. Alzheimers Dement, 2017, 3(2): 247-253.
69 CotelliM, ManentiR, BrambillaM, et al. A nodal tDCS during face-name associations memory training in Alzheimer's patients [J]. Front Aging Neurosci, 2014, 6: 38.
70 MarcegliaS, Mrakic-SpostaS, RosaM, et al. Transcranial direct current stimulation modulates cortical neuronal activity in Alzheimer's disease [J]. Front Neurosci, 2016, 10: 134.
71 KesslerS K, TurkeltaubP E, BensonJ G, et al. Differences in the experience of active and sham transcranial direct current stimulation [J]. Brain Stimul, 2012, 5(2): 155-162.
72 FloelA, MeinzerM, KirsteinR, et al. Short-term anomia training and electrical brain stimulation [J]. Stroke, 2011, 42(7): 2065-2067.
73 BenwellC S, LearmonthG, MiniussiC, et al. Non-linear effects of transcranial direct current stimulation as a function of individual baseline performance: Evidence from biparietal tDCS influence on lateralized attention bias [J]. Cortex, 2015, 69: 152-165.
74 HsuT Y, JuanC H, TsengP. Individual differences and state-dependent responses in transcranial direct current stimulation [J]. Front Hum Neurosci, 2016, 10: 643.
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