Advance in Relationship between Autism Spectrum Disorders and Microbiome (review)

  • ZHANG Chun-yan ,
  • ZHU Lu-wen ,
  • TANG Qiang
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  • 1.Rehabilitation Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China
    2.The Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China

Received date: 2019-01-15

  Revised date: 2019-02-26

  Online published: 2019-04-02

Supported by

Heilongjiang University of Chinese Medicine Project (No. 201517) and the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Project (No. YM-201704)

Abstract

It has been increasingly recognized that the presence of a healthy and diverse gut microbiota is important to the development of central nervous system and emotional processing for children with autism spectrum disorders (ASD). The interconnection of gut microbiome and brain function has significantly contributed to establishing the microbiota-gut-brain axis as an extension of the well-accepted gut-brain axis concept. The bidirectional interaction between the gut microbiota and the brain occurs through various pathways including serotonin, hypothalamus-pituitary-adrenal axis, neurotrophin, and the immune system. The microbiota-gut-brain axis has been shown to influence the behaviors associated with neuropsychiatric conditions. Modulation of this gut microbiota as a novel therapy for ASD is gaining interest. This paper summarized the status of neuropsychological microbiome, which provided evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms.

Cite this article

ZHANG Chun-yan , ZHU Lu-wen , TANG Qiang . Advance in Relationship between Autism Spectrum Disorders and Microbiome (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(3) : 319 -323 . DOI: 10.3969/j.issn.1006-9771.2019.03.013

References

1 BaioJ, WigginsL, ChristensenD L, et al. Prevalence of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States [J]. MMWR Surveill Summ, 2018, 67(6): 1-23.
2 ChaidezV, HansenR L, Hertz-PicciottoI. Gastrointestinal problems in children with autism, developmental delays or typical development [J]. J Autism Dev Disord, 2014, 44(5): 1117-1127.
3 DesbonnetL, ClarkeG, ShanahanF, et al. Microbiota is essential for social development in the mouse [J]. Mol Psychiatry, 2014, 19 (2): 146-148.
4 DinanT G, BorreY E, CryanJ F. Genomics of schizophrenia: time to consider the gut micbiome? [J]. Mol Psychiatry, 2014, 19(12): 1252-1257.
5 HsiaoE Y, McBrideS W, HsienS, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders [J]. Cell, 2013, 155(7): 1451-1463.
6 de TheijeC G, WopereisH, RamadanM, et al. Altered gut microbiota and activity in a murine model of autism spectrum disorders [J]. Brain Behav Immun, 2014, 37: 197-206.
7 CorettiL, CristianoC, FlorioE, et al. Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder [J]. Sci Rep, 2017, 28: 201-208.
8 SqrittaM, DoolingS W, BuffingtonS A, et al. Mechanisms Underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder [J]. Neuron, 2019, 101(2): 246-259.e6.
9 OssenkoppK P, FoleyK A, GibsonJ, et al. Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats [J]. Behav Brain Res, 2012, 227 (1): 134-141.
10 WallR, CryanJ F, RossR P, et al. Bacterial neuroactive compounds produced by psychobiotics [J]. Adv Exp Med Biol, 2014, 817: 221-239.
11 NankovaB B, AgarwalR, MacFabeD F. Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells-possible relevance to autism spectrum disorders [J]. PLoS One, 2014, 9(8): e103740.
12 VuongH E, HsiaoE Y. Emerging roles for the gut microbiome in autism spectrum disorder [J]. Biol Psychiatry, 2017, 81(5): 411-423.
13 WangL, ChristophersenC T, SorichM J, et al. Increased abundance of Sutterella spp. and Rumincoccus torques in feces of children with autism spectrum disorder [J]. Mol Autism, 2013, 4(1): 42.
14 StratiF, CavalieriD, AlbaneseD, et al. New evidences on the altered gut microbiota in autism spectrum disorders [J]. Microbiome, 2017, 5(1): 24.
15 IoveneM R, BombaceF, MarescaR, et al. Intestinal dysbiosis and yeast isolation in stool of subjects with autism spectrum disorders [J]. Mycopathologia, 2017, 182 (3-4): 349-363.
16 GrossiE, MelliS, DuncaD, et al. Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics [J]. SAGE Open Med Case Rep, 2016, 26: 4.
17 SantocchiE, GuiducciL, FulceriF, et al. Gut to brain interaction in autism spectrum disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters [J]. BMC Psychiatry, 2016, 16: 183.
18 MalhiP, VenkateshL, BhartiB, et al. Feeding problems and nutrient intake in children with and without autism: a comparative study [J]. Indian J Pediatr, 2017, 84 (4): 283-288.
19 PennesiC M, KleinL C. Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: based on parental report [J]. Nutr Neurosci, 2012, 15(2): 85-91.
20 NewellC, BomhofM R, ReimerR A, et al. Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder [J]. Mol Autism, 2016, 7 (1): 37.
21 FinegoldS M. Desulfovibrio species are potentially important in regressive autism [J]. Med Hypotheses, 2011, 77 (2): 270-274.
22 PetraA I, PanagintidouS, HatziagelakiE, et al. Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation [J]. Clin Ther, 2015, 37(5): 984-995.
23 IsraelyanN, MargolisK G. Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders [J]. Pharmacol Res, 2019, 140: 115-120.
24 HombergJ R, KolkS M, SchubertD, et al. Editorial perspective of the research topic “Deciphering Serotonin's Role in Neurodevelopment” [J]. Front Cell Neurosci, 2013, 7: 212.
25 MulderE J, AndersonG M, KemaI P, et al. Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates [J]. J Am Acad Child Adolesc Psychiatry, 2004, 43 (4): 491-499.
26 FinegoldS M. Desulfovibrio species are potentially important in regressive autism [J]. Med Hypotheses, 2011, 77(2): 270-274.
27 ReigstadC S, SalmonsonC E, RaineyJ F, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells [J]. FASEB J, 2015, 29 (4): 1395-1403.
28 Sj?grenK, EngdahlC, HenningP, et al. The gut microbiota regulates bone mass in mice [J]. J Bone Miner Res, 2012, 27: 1357-1367.
29 白志余,周东蕊,张仁敏,等.肠内代谢物腹腔注射对大鼠神经内分泌和行为学的影响[J].中国现代医学杂志, 2016, 26(19): 17-22.
30 李佳帅,唐强,朱路文,等.肠道菌群功能及其与运动的相关性研究进展[J].中国康复理论与实践, 2018, 24(12): 1422-1424.
31 TakeuchiO, AkiraS. Pattern recognition receptors and inflammation [J]. Cell, 2010, 140(6): 805-820.
32 LutgendorffF, AkkermansL M, S?derholmJ D. The role of microbiota and probiotics in stress induced gastro-intestinal damage [J]. Curr Mol Med, 2008, 8(4): 282-298.
33 KeitaA V, S?derholmJ D. The intestinal barrier and its regulation by neuroimmune factors [J]. Neurogastroenterol Motil, 2010, 22(7): 718-733.
34 KarczewskiJ, TroostF J, KoningsI, et al. Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier [J]. Am J Physiol Gastrointest Liver Physiol, 2010, 298(6): G851-G859.
35 HolmesA S, BlaxillM F, HaleyB E. Reduced levels of mercury in first baby haircuts of autistic children [J]. Int J Toxicol, 2003, 22(4): 277-285.
36 陈保林,何慕兰,雷雨溪,等.脂多糖诱导孤独症样大鼠的肠道通透性及肠道黏膜免疫系统的变化[J].免疫学杂志, 2019, 35(1): 12-28.
37 FerqusonB J, MarlerS, AltsteinL L, et al. Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder [J]. Brain Behav Immun, 2016, 58: 57-62.
38 洪南,湛先保. 肠道微生态系统与肠粘膜免疫关系研究进展[J]. 医学研究学院, 2014, 27(4): 444-446.
39 GurT L, BaileyM T. Effects of stress on commensal microbes and immune system activity [J]. Adv Exp Med Biol, 2016, 874: 289-300.
40 陆高,孙建华.CRH-NLRP6-微生物轴在肠易激综合征发病机制及其治疗中的作用[J].医学研究生学报, 2016, 29(1): 92-96.
41 Crumeyrolle-AriasM, JaglinM, BruneauA, et al. Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats [J]. Psychoneuroendocrinology, 2014, 42: 207-217.
42 RookG A, LowryC A, RaisonC L, et al. Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer? [J]. Brain Behav Immun, 2011, 25 (4): 591-601.
43 FergusonB J, MarlerS, AltsteinL L, et al. Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder [J]. Brain Behav Immun, 2016, 58: 57-62.
44 潘俊希,谢鹏.神经精神疾病微生物组研究现状和展望[J].生命科学, 2017, 29(7): 669-681.
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