Objective To compare the effects of Botulinum toxin type A (BTX-A) injection guided with electromyographic/electric stimulation or ultrasonography in patients with post-stroke spasticity of wrist and finger flexor muscles. Methods Inpatients with post-stroke spasticity of wrist and finger flexor muscles accepted BTX-A injection from January, 2015 to May, 2019 were reviewed. They were divided into electromyographic/electric stimulation-guided group (n = 36) and ultrasound-guided group (n = 37). They were assessed with modified Ashworth Scale (MAS) and Fugl-Meyer Assessment (FMA) before injection and four weeks after treatment. Results The scores of both MAS and FMA improved in both groups after treatment (|Z| > 4.654, P < 0.001), and the scores of MAS improved more in the ultrasound-guided group (|Z| > 1.980, P < 0.05), with less dosage of BTX-A (t = 4.023, P < 0.001). Conclusion Ultrasound-guided injection of BTX-A is more effective on wrist and finger flexion muscles spasticity than electromyographic/electric stimulation-guided method in stroke patients.
LU Hai-tao
,
CUI Li-hua
,
WANG Yi-zheng
. Comparation of Effects of Botulinum Toxin Type A Injection under Different Guidance Approaches on Wrist and Finger Spasticity in Stroke Patients[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019
, 25(11)
: 1352
-1355
.
DOI: 10.3969/j.issn.1006-9771.2019.11.017
1 WisselJ, ManackA, BraininM. Toward an epidemiology of poststroke spasticity [J]. Neurology, 2013, 80(3 Suppl 2): S13-S19.
2 UrbanP P, WolfT, UebeleM, et al. Occurence and clinical predictors of spasticity after ischemic stroke [J]. Stroke, 2010, 41(9): 2016-2020.
3 WisselJ, VerrierM, SimpsonD M, et al. Post-stroke spasticity: predictors of early development and considerations for therapeutic intervention [J]. PM R, 2015, 7(1): 60-67.
4 SimpsonD M, HallettM, AshmanE J, et al. Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache: report of the Guideline Development Subcommittee of the American Academy of Neurology [J]. Neurology, 2016, 86(19): 1818-1826.
5 WisselJ, WardA B, ErztgaardP, et al. European consensus table on the use of Botulinum toxin type A in adult spasticity [J]. J Rehabil Med, 2009, 41(1): 13-25.
6 GrigoriuA I, DinomaisM, Remy-NerisO, et al. Impact of injection-guiding techniques on the effectiveness of Botulinum toxin for the treatment of focal spasticity and dystonia: a systematic review [J]. Arch Phys Med Rehabil, 2015, 96(11): 2067-2078.
7 中华神经科学会,中华神经外科学会. 各类脑血管病诊断要点[J]. 中华神经科杂志, 1996, 29(6): 379-380.
8 KaraM, KaymakB, UlasliA M, et al. Sonographic guide for Botulinum toxin injections of the upper limb: EUROMUSCULUS/USPRM spasticity approach [J]. Eur J Phys Rehabil Med, 2018, 54(3): 469-485.
9 JiangL, DouZ L, WangQ, et al. Evaluation of clinical outcomes of patients with post-stroke wrist and finger spasticity after ultrasonography-guided BTX-A injection and rehabilitation training [J]. Ann Rehabil Med, 2015, 9: 485.
10 BuyukavciR, AkturkS, ErsoyY. Evaluating the functional outcomes of ultrasound-guided Botulinum toxin type A injections using the Euro-musculus approach for upper limb spasticity treatment in post-stroke patients: an observational study [J]. Eur J Phys Rehabil Med, 2018, 54(5): 738-744.
11 GraciesJ M. Pathophysiology of spastic paresis. I: Paresis and soft tissue changes [J]. Muscle Nerve, 2005, 31(5): 535-551.
12 GraciesJ M. Pathophysiology of spastic paresis. II: Emergence of muscle overactivity [J]. Muscle Nerve, 2005, 31(5): 552-571.
13 PicelliA, RoncariL, BaldessarelliS, et al. Accuracy of Botulinum toxin type A injection into the forearm muscles of chronic stroke patients with spastic flexed wrist and clenched fist: manual needle placement evaluated using ultrasonography [J]. J Rehabil Med, 2014, 46(10): 1042-1045.
14 SantamatoA, MicelloM F, PanzaF, et al. Can Botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniques [J]. J Neurol Sci, 2014, 347(1-2): 39-43.
15 KaymakB, KaraM, Yagiz OnA, et al. Innervation zone targeted Botulinum toxin injections [J]. Eur J Phys Rehabil Med, 2018, 54(1): 100-109.
16 WalkerF O, CartwrightM S, WieslerE R, et al. Ultrasound of nerve and muscle [J]. Clin Neurophys, 2004, 115(3): 495-507.
17 AkturkS, BuyukavciR, ErsoyY. Functional outcomes following ultrasound-guided Botulinum toxin type A injections to reduce spastic equinovarus in adult post-stroke patients [J]. Toxicon, 2018, 146(2.276): 95-98.
18 GraciesJ M, BrashearA, JechR, et al. Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial [J]. Lancet Neurol, 2015, 14(10): 992-1001.