CJRTP

Chinese Journal of Rehabilitation Theory and Practice >

2020 , Vol. 26 >Issue 5: 544 - 549

DOI: https://doi.org/10.3969/j.issn.1006-9771.2020.05.010

Effects of Electroacupuncture on Brain Function of APP/PS1 Mice: A Functional Magnetic Resonance Imaging Study

  • Le LI ,
  • Sheng HUANG ,
  • Long LI ,
  • Jia-yong ZHANG ,
  • Ting-ting JIN ,
  • Yu-hao ZHANG ,
  • Bing-xue ZHANG ,
  • Min-guang YANG ,
  • Sheng-xiang LIANG ,
  • Zhi-fu WANG ,
  • Wei-lin LIU ,
  • Jing TAO ,
  • Li-dian CHEN
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  • 1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
    2. Fujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, China
    3. Technology Innovation Platform of Fujian Rehabilitation Industry Research Institute, Fuzhou, Fujian 350122, China
    4. Rehabilitation Research Center of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China

Received date: 2019-08-10

  Revised date: 2019-09-18

  Online published: 2020-05-29

Supported by

National Natural Science Foundation of China(81774424)

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Abstract

Objective To investigate the effects of electroacupuncture at Baihui (DU20) and Shenting (DU24) on brain function of APP/PS1 mice.Methods Sixteen 4-month-old APP/PS1 mice in the same litter were randomly divided into model group (n = 8) and electroacupuncture group (n = 8). Eight transgenic negative mice in the same litter were as control group. The electroacupuncture group accepted electroacupuncture at Baihui and Shenting for 16 weeks. They were assessed withObject Recognition Test before and after intervention, and observed under small animal functional magnetic resonance imaging with regional homogeneity (ReHo) analysis.Results Compared with the control group, the discrimination ratio decreased in the model group after intervention (P < 0.05), while it increased in the electroacupuncture group compared with that in the model group ( P < 0.05). Compared with the control group, ReHo of right basal forebrain and left hippocampus decreased in the model group before intervention. Compared with the control group, ReHo decreased in bilateral hippocampus group and increased in retrosplenial cortex in the model group after intervention; while it increased in bilateral hippocampus and motor cortex and decreased in anterior cingulate gyrus in the electroacupuncture group compared with that in the model group. Conclusion Electroacupuncture at Baihui and Shenting may delay the decline of learning and memory ability in Alzheimer's disease model mice, which may relate to the regulation of functional activities in hippocampus.

Key words： Alzheimer's disease; electroacupuncture; learning and memory; brain function; functional magnetic resonance imaging; mice

Cite this article

Le LI , Sheng HUANG , Long LI , Jia-yong ZHANG , Ting-ting JIN , Yu-hao ZHANG , Bing-xue ZHANG , Min-guang YANG , Sheng-xiang LIANG , Zhi-fu WANG , Wei-lin LIU , Jing TAO , Li-dian CHEN . Effects of Electroacupuncture on Brain Function of APP/PS1 Mice: A Functional Magnetic Resonance Imaging Study[J]. Chinese Journal of Rehabilitation Theory and Practice, 2020 , 26(5) : 544 -549 . DOI: 10.3969/j.issn.1006-9771.2020.05.010

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