CJRTP

Chinese Journal of Rehabilitation Theory and Practice >

2020 , Vol. 26 >Issue 5: 572 - 578

DOI: https://doi.org/10.3969/j.issn.1006-9771.2020.05.016

Functional Connectivities in Right Hemisphere for Post-stroke Aphasia: Based on Dual Stream Model

  • Rui-wen FAN ,
  • Xiao-lin LI ,
  • Xing HUANG ,
  • Min-jie XU ,
  • Yun CAO ,
  • Dan-li ZHANG ,
  • Jing-ling CHANG
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  • Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Received date: 2019-12-17

  Revised date: 2020-01-17

  Online published: 2020-05-29

Supported by

Beijing Natural Science Foundation(7181005);National Science Foundation of China(81973790);Beijing University of Chinese Medicine Research and Innovation Team(2019-JYB-TD003)

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Abstract

Objective To study the effect of right brain language network in post-stroke aphasia (PSA) patients with left hemisphere injury.Methods From December, 2018 to June, 2019, twelve PSA patients with left hemisphere injury, and twelve matched healthy controls were recruited to accept rest-state functional magnetic resonance imaging (f-MRI) scan, and analyzed the characteristics of right brain function network with Dual Stream model.Results There were two patients lost. Compared with the controls, for dorsolateral lingual pathway, the functional connections increased from superior marginal gyrus to middle frontal gyrus and inferior frontal gyrus of trigone in the patients, while those decreased from posterior central gyrus to inferior frontal gyrus of insula. For ventral lingual pathway, the functional connection increased from angular gyrus to orbital inferior frontal gyrus. For ventral and dorsolateral double-pathway, the functional connections increased from temporal lobe to lenticular pallidum and angular gyrus, from caudate nucleus to inferior frontal gyrus of insula, from lenticular putamen nucleus to middle frontal gyrus and trigonometry, while it decreased from superior marginal gyrus and temporal lobe to inferior frontal gyrus of insula. There was a negative correlation between the functional connection from inferior frontal gyrus to lenticular putamen and repeating (r = -0.720, P < 0.05), between the functional connection from inferior frontal gyrus to the caudate nucleus to speaking and repeating ( r < -0.696, P < 0.05). In terms of network index, there were significant differences between the patients and the controls in both local and global indexes for language key brain area in right brain (| t| > 2.143, P < 0.05). Conclusion The functional network has reorganized in right hemisphere of PSA patients. However, the increase of connection between language critical cortex and subcortical nuclei may play a role in improvement of language function.

Key words： stroke; aphasia; dual stream model; brain function network; right brain

Cite this article

Rui-wen FAN , Xiao-lin LI , Xing HUANG , Min-jie XU , Yun CAO , Dan-li ZHANG , Jing-ling CHANG . Functional Connectivities in Right Hemisphere for Post-stroke Aphasia: Based on Dual Stream Model[J]. Chinese Journal of Rehabilitation Theory and Practice, 2020 , 26(5) : 572 -578 . DOI: 10.3969/j.issn.1006-9771.2020.05.016

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