CJRTP

Chinese Journal of Rehabilitation Theory and Practice >

2020 , Vol. 26 >Issue 7: 757 - 765

DOI: https://doi.org/10.3969/j.issn.1006-9771.2020.07.004

Motor Control Function of Brain in Subacute Complete Spinal Cord Injured Patients: A Functional Magnetic Resonance Imaging Study

  • Shu-jia LIU ,
  • Jun-wei ZHANG ,
  • Fang-yong WANG ,
  • He-hu TANG ,
  • Jin-zhu BAI ,
  • Zhen LÜ ,
  • Jian-jun LI
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  • 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
    2. Department of Spine and Spinal Cord Surgery, China Rehabilitation Research Center, Beijing 100068, China
    3. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China
    4. Beijing Key Laboratoryof Neural Injury and Rehabilitation, Beijing 100068, China

Received date: 2020-04-05

  Revised date: 2020-05-01

  Online published: 2020-07-24

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Abstract

Objective To study the changes of brain motor control function in patients with complete spinal cord injury within three to six months. Methods From January, 2017 to January, 2019, eleven inpatients with complete spinal cord injury and twelve healthy controls were screened with functional magnetic resonance imaging during attempted/executive movement (MA/ME) and motor imagery (MI). The involved area and activation were compared between the groups under tasks. Results More areas were activated in the patients than in the controls as MA/ME, such as bilateral primary sensorimotor cortex, supplementary motor area, lateral globus pallidus, cerebellum, contralateral thalamus and putamen. During MI, the activation was more in the patients in ipsilateral primary motor cortex, supplementary motor area, dorsal premotor area, contralateral supplementary motor area, insular and basal ganglia. The patients induced more activation as MA than as MI in ipsilateral primary motor cortex, bilateral supplementary motor area and cingulate motor area, and contralateral cerebellum.Conclusion The activation remains normal in primary motor cortex and supplementary motor area for subacute complete spinal cord injury patients when undergoing motor tasks, but some reorganization may occur in parietal lobe and cerebellum that involve in sensorimotor integration.

Key words： spinal cord injury; brain function; motor control; functional magnetic resonance imaging

Cite this article

Shu-jia LIU , Jun-wei ZHANG , Fang-yong WANG , He-hu TANG , Jin-zhu BAI , Zhen LÜ , Jian-jun LI . Motor Control Function of Brain in Subacute Complete Spinal Cord Injured Patients: A Functional Magnetic Resonance Imaging Study[J]. Chinese Journal of Rehabilitation Theory and Practice, 2020 , 26(7) : 757 -765 . DOI: 10.3969/j.issn.1006-9771.2020.07.004

References

[1] Lebedev M A, Nicolelis M A. Brain-machine interfaces: from basic science to neuroprostheses and neurorehabilitation[J]. Physiol Rev, 2017, 97(2): 767-837.
[2] Oni-Orisan A, Kaushal M, Li W, et al. Alterations in cortical sensorimotor connectivity following complete cervical spinal cord injury: a prospective resting-state fMRI study[J]. PLoS One, 2016, 11(3): e0150351.
[3] Rao J S, Manxiu M, Zhao C, et al. Atrophy and primary somatosensory cortical reorganization after unilateral thoracic spinal cord injury: a longitudinal functional magnetic resonance imaging study[J]. Biomed Res Int, 2013, 2013:753061.
[4] Kew J J, Ridding M C, Rothwell J C, et al. Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation[J]. J Neurophysiol, 1994, 72(5): 2517-2524.
[5] Jutzeler C R, Curt A, Kramer J L. Relationship between chronic pain and brain reorganization after deafferentation: a systematic review of functional MRI findings[J]. Neuroimage Clin, 2015, 9:599-606.
[6] Zhu L, Wu G, Zhou X, et al. Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI[J]. PLoS One, 2015, 10(3): e0118816.
[7] Rammond D J. Motor imagery: never in your wildest dream[J]. Trend Neurosci, 1997, 20(2): 54-57.
[8] Seif M, Curt A, Thompson A J, et al. Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury[J]. Neuroimage Clin, 2018, 20:556-563.
[9] Vahdat S, Lungu O, Cohen-Adad J, et al. Simultaneous brain-cervical cord fMRI reveals intrinsic spinal cord plasticity during motor sequence learning[J]. PLoS Biol, 2015, 13(6): e1002186.
[10] Mohammed H, Hollis E R 2nd. Cortical reorganization of sensorimotor systems and the role of intracortical circuits after spinal cord injury[J]. Neurotherapeutics, 2018, 15(3): 588-603.
[11] Moxon K A, Oliviero A, Aguilar J, et al. Cortical reorganization after spinal cord injury: always for good?[J]. Neuroscience, 2014, 283:78-94.
[12] Saruco E, Guillot A, Saimpont A, et al. Motor imagery ability of patients with lower-limb amputation: exploring the course of rehabilitation effects[J]. Eur J Phys Rehabil Med, 2019, 55(5): 634-645.
[13] Smith A C, Weber K A, Parrish T B, et al. Ambulatory function in motor incomplete spinal cord injury: a magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry[J]. Spinal Cord, 2017, 55(7): 672-678.
[14] Kirshblum S C, Burns S P, Biering-Sorensen F, et al. International Standards for Neurological Classification of Spinal Cord Injury (revised 2011)[J]. J Spinal Cord Med, 2011, 34(6): 535-546.
[15] Wang Y, Li G, Luk K D K, et al. Component analysis of somatosensory evoked potentials for identifying spinal cord injury location[J]. Sci Rep, 2017, 7(1): 2351.
[16] Isaac A, Marks D, Russell E. An instrument for assessing imagery of movement: the Vividness of Movement Imagery Questionnaire (VMIQ)[J]. J Mental Imag, 1986, 10:23-30.
[17] 魏鹏绪, 鲍瑞雪, 张通, 等. 刺激下肢不同穴位在双侧感觉皮质引发的激活效应差异[J]. 中国康复医学杂志, 2010, 25(12): 1144-1147.
[17] Wei P X, Bao R X, Zhang T, et al. Discrepancy in effects of stimulating different acupoints of unilateral lower extremities on activation responses in bilateral primry somatosensory cortices[J]. Chin J Rehabil Med, 2010, 25(12): 1144-1147.
[18] Lee B H, Lee K H, Kim U J, et al. Injury in the spinal cord may produce cell death in the brain[J]. Brain Res, 2004, 1020(1-2): 37-44.
[19] Hawasli A H, Rutlin J, Roland J L, et al. Spinal cord injury disrupts resting-state networks in the human brain[J]. J Neurotrauma, 2018, 35(6): 864-873.
[20] Serradj N, Agger S F, Hollis E R. Corticospinal circuit plasticity in motor rehabilitation from spinal cord injury[J]. Neurosci Lett, 2017, 23(652): 94-104.
[21] Dias Leao M T, Wiesinger L, Ziemann U, et al. Rapid motor cortical reorganization following subacute spinal cord dysfunction[J]. Brain Stimul, 2020, 13(3): 783-785.
[22] Sharp K G, Gramer R, Page S J, et al. Increased brain sensorimotor network activation after incomplete spinal cord injury[J]. J Neurotrauma, 2017, 34(3): 623-631.
[23] Liu S J, Wang Y, Wei P X, et al. Brain motor control function in a patient with subacute, incomplete, asymmetrical spinal cord injury[J]. Chin Med J, 2010, 123(13): 1812-1814.
[24] Porro C A, Francescato M P, Cettolo V, et al. Primary motor and sensory cortex activation during motor performance and motor imagery: a functional magnetic resonance imaging study[J]. J Neurosci, 1996, 16(23): 7688-7698.
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