人颞叶内侧癫痫海马组织星形胶质细胞Syntrophin的表达变化

doi:10.3969/j.issn.1006-9771.2017.03.009

Abstract

Abstract: ObjectiveTo investigate the expression changes of astrocytic syntrophin in hippocampus from human mesial temporal lobe epilepsy (MTLE). MethodsFrom April, 2015 to July, 2016, 17 cases of hippocampus, collected from temporal lobectomy, were divided into MTLE group (n=13) and non-MTLE group (n=4) according to hematoxylin and eosin staining, glial fibrillary acidic protein and neuronal nuclei immunohistochemical staining. Immunofluorescence double labeling and immunofluorescence histochemistry were used to observe the expression of syntrophin. ResultsThe proliferation of astrocytes increased and neurons reduced in the hippocampus of MTLE group. Syntrophin was found in the membrane and foot processes of astrocyte, that was enriched along perivascular astrocyte end-feet domain in non-MTLE group, but lost in MTLE group. While the whole expression of syntrophin was more in MTLE group than in non-MTLE group (t=5.421, P<0.001). ConclusionThe distribution of syntrophin in hippocampus astrocytes may be related to the development of MTLE.

Key words: mesial temporal lobe epilepsy, hippocampus, astrocyte, syntrophin, dystrophin-associated glycoprotein complex

CLC Number:

R742.1

WANG Xiao-xuan, SUN Zhen-rong, WU Min, SHI Zhong-fang, YAN Xu, XU Li-xin, DONG Li-ping, YANG Shao-hua, YUAN Fang. Distribution of Astrocytic Syntrophin in Hippocampus from Human Mesial Temporal Lobe Epilepsy[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(3): 292-297.

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Distribution of Astrocytic Syntrophin in Hippocampus from Human Mesial Temporal Lobe Epilepsy

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