《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2017, Vol. 23 ›› Issue (3): 363-369.doi: 10.3969/j.issn.1006-9771.2017.03.025

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Effects of Repetitive Transcranial Magnetic Stimulation on Unilateral Spatial Neglect in Patients with Stroke: A Meta-analysis

YANG Yu-jie1, ZHU Yi2, CHENG Jie1, GUO Jia-bao1, GUO Hai-ying1   

  1. 1. The Second Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China;
    2. Rehabilitation Center, Hainan Provincial Nongken General Hospital, Haikou, Hainan 570000, China
  • Received:2017-01-01 Published:2017-03-05 Online:2017-03-31
  • Contact: Correspondence to GUO Hai-ying. E-mail: ghying63@126.com

Abstract: ObjectiveTo evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) on unilateral spatial neglect in stroke patients. MethodsPublished articles from the earliest date available to July, 2016 were recalled from PubMed, OVID, Embase, Cochrane Library, CNKI, VIP and Wanfang Database. Two reviewers selected independently the randomized controlled trials (RCTs) about rTMS for stroke patients with unilateral spatial neglect, and extracted data independently and analyzed with RevMan 5.3 and GRADE profiler 3.6. ResultsTwelve trials that represented 353 participants were evaluated. For improving Line Bisection Test, Star Cancellation Test, Albert Test, rTMS groups were significantly more effective than the controls. rTMS groups with different frequencies all showed significantly effective: for low frequency rTMS, SMD=-1.21, 95%CI=-2.17 to -0.25; for high frequency rTMS, SMD=-2.56, 95%CI=-3.54 to -1.58; for continuous theta burst stimulation (cTBS), SMD=-2.51, 95%CI=-3.66 to -1.36. ConclusionrTMS is effective on unilateral spatial neglectin in stroke patients.

Key words: stroke, unilateral spatial neglect, repetitive transcranial magnetic stimulation, meta-analysis

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