›› 2019, Vol. 25 ›› Issue (5): 540-545.doi: 10.3969/j.issn.1006-9771.2019.05.007

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Advance in Interleukin-6 in Central Nervous System (review)

LIU Qiu-yan, ZHANG Lei-hong, YU Xiao-ming, YUAN Ai-yun   

  1. Department of Neurological Rehabilitation, Qingdao Women and Children’s Hospital, Qingdao, Shandong 266034, China
  • Received:2018-11-16 Revised:2018-12-20 Online:2019-05-25 Published:2019-05-29
  • Contact: YUAN Ai-yun, E-mail: yay79429@126.com
  • Supported by:
    Projects of Medical and Health Technology Development Program in Shandong Province (No. 2015WS0352), the Projects of Medical Science Guidance Program in Qingdao City (No. 2016-WJZD084) and the Qingdao Outstanding Health Professional Development Fund (No. 2017.1-2019.12).

Abstract: The central nervous system can produce a variety of neuroimmune factors including interleukin-6. This article reviewed the expression and signaling pathways of interleukin-6 and its receptors in the central nervous system, and advances in interleukin-6 in the regulation of central nervous system related diseases, cognitive behaviors and synaptic function, which suggested that interleukin-6 involves in various physiological or pathological functions in the central nervous system and affects central nervous system in multiple layers such as protein expression, signal transduction, neurological function, and synaptic transmission. Interleukin-6 is expected to be a biological marker in the specific state of the central nervous system. In addition, interleukin-6 can regulate the function of neurons and synapses and is an important molecule involved in synaptic transmission, synaptic plasticity, and learning and memory. Strengthening the research on the biological function and mechanism of interleukin-6 and timely regulating the interleukin-6 expression will provide a new perspective for the treatment of the central nervous system related diseases.

Key words: interleukin-6, nerve, synapse, cognition, review

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